Comparison of Carboplatin With Cisplatin in Small Cell Lung Cancer in US Veterans
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.37699
Abstract: Key Points Question What is the platinum agent of choice in treating small cell lung cancer (SCLC), cisplatin or carboplatin? Findings In this cohort study of 4408 patients at US Veteran Affairs hospitals, there was… read more here.
Keywords: lung cancer; carboplatin; small cell; carboplatin cisplatin ... See more keywords
Anaemia and pathologic complete response rate according to carboplatin dose in HER2+ breast cancer treated with neoadjuvant TCHP
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5022
Abstract: Grade 3/4 anaemia, which is mainly induced by carboplatin, frequently occurs in patients treated with neoadjuvant docetaxel/carboplatin/trastuzumab/pertuzumab (TCHP). However, dose reduction of carboplatin may raise concerns about the oncological outcome. This study investigated the pathologic… read more here.
Keywords: tchp; carboplatin; treated neoadjuvant; rate ... See more keywords
Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3890
Abstract: Carboplatin is a chemotherapy drug used to treat solid tumors but also causes bone loss and muscle atrophy and weakness. Bone loss contributes to muscle weakness through bone‐muscle crosstalk, which is prevented with the bisphosphonate… read more here.
Keywords: muscle; bone; mice treated; carboplatin ... See more keywords
An Exposure-Response Model with Time-Varying Predictors to Estimate the Effects of Veliparib in Combination With Carboplatin/Paclitaxel and as Monotherapy: Veliparib Phase 3 Study in BRCA-Mutated Advanced Breast Cancer (BROCADE3) Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2061
Abstract: BROCADE3 is a Phase 3 study, evaluating veliparib in combination with carboplatin/paclitaxel with continuation as monotherapy if carboplatin/paclitaxel is discontinued in patients with germline BRCA1/2 mutation-associated, advanced HER2-negative breast cancer. The objective of the current… read more here.
Keywords: combination carboplatin; carboplatin paclitaxel; carboplatin; monotherapy ... See more keywords
A phase I study to assess afatinib in combination with carboplatin or with carboplatin plus paclitaxel in patients with advanced solid tumors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3661-1
Abstract: PurposeAfatinib, an irreversible ErbB family blocker, has demonstrated preclinical antitumor activity with chemotherapy.MethodsAs part of a phase I trial in patients with advanced solid tumors (NCT00809133; 3 + 3 dose-escalation design), we determined the maximum tolerated dose… read more here.
Keywords: solid tumors; advanced solid; carboplatin carboplatin; carboplatin ... See more keywords
A phase II randomized controlled study of pegylated liposomal doxorubicin and carboplatin vs. gemcitabine and carboplatin for platinum-sensitive recurrent ovarian cancer (GOTIC003/intergroup study)
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-019-01471-5
Abstract: PurposeTo compare the efficacy, safety, and tolerability profiles of pegylated liposomal doxorubicin and carboplatin (PLDC) with those of gemcitabine and carboplatin (GC) for the treatment of patients with platinum-sensitive recurrent ovarian cancer.MethodsOvarian cancer patients with… read more here.
Keywords: pegylated liposomal; study; carboplatin; cancer ... See more keywords
Temporary blood–brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03204-0
Abstract: IntroductionGlioblastoma (GBM) is the most common and aggressive primary brain cancer in adults. Few cytotoxic chemotherapies have been shown to be effective against GBM, due in part to the presence of the blood–brain barrier (BBB),… read more here.
Keywords: blood brain; bbb; carboplatin; brain barrier ... See more keywords
Phase II Trial on the Feasibility of Single-Dose Intraoperative Intraperitoneal Carboplatin in Advanced Epithelial Ovarian Cancer Following Optimal Cytoreductive Surgery
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Surgical Oncology"
DOI: 10.1007/s13193-020-01197-1
Abstract: To evaluate the feasibility administering single-dose intraoperative intraperitoneal carboplatin (IP) in advanced epithelial ovarian cancer (EOC) after optimal primary or interval debulking surgery. A phase II non-randomized prospective study conducted at a regional cancer institute… read more here.
Keywords: epithelial ovarian; dose intraoperative; carboplatin; cancer ... See more keywords
Carboplatin as an alternative to Cisplatin in chemotherapies: New insights at single molecule level.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2018.07.004
Abstract: Here we report a new study performed at single molecule level on the interaction of the antineoplastic drug Carboplatin and the DNA molecule - the main target of the drug inside cells in cancer chemotherapies.… read more here.
Keywords: molecule; single molecule; cisplatin; molecule level ... See more keywords
Efficacy of neurokinin-1 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting in patients receiving carboplatin-based chemotherapy: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2018.02.001
Abstract: According to current ESMO - MASCC guidelines, a combination of a neurokinin-1 receptor antagonist (NK1RA), dexamethasone and a 5-HT3 receptor antagonist (5-HT3RA) is recommended to prevent carboplatin-induced emesis, albeit with moderate level of confidence and… read more here.
Keywords: chemotherapy; patients receiving; based chemotherapy; carboplatin ... See more keywords
Carboplatin versus two doses of cisplatin in combination with gemcitabine in the treatment of advanced non-small-cell lung cancer: Results from a British Thoracic Oncology Group randomised phase III trial
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Cancer"
DOI: 10.1016/j.ejca.2017.05.037
Abstract: Background Platinum-based combination chemotherapy is standard treatment for the majority of patients with advanced non-small-cell lung cancer (NSCLC). The trial investigates the importance of the choice of platinum agent and dose of cisplatin in relation… read more here.
Keywords: combination; trial; treatment; carboplatin ... See more keywords