Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes
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DOI: 10.3390/ijms23116290
Abstract: Chemotherapy-induced thrombocytopenia (CIT) is a common complication when treating malignancies with cytotoxic agents wherein carboplatin is one of the most typical agents causing CIT. Janus kinase 2 (JAK2) is one of the critical enzymes to… read more here.
Keywords: cell; cell cycle; carboplatin induced; induced thrombocytopenia ... See more keywords
COM33 suppresses carboplatin-induced epithelial-mesenchymal transition via inhibition of Twist1 in ovarian cancer
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DOI: 10.3724/abbs.2022195
Abstract: Despite favorable responses to platinum-based chemotherapy in ovarian cancer (OC), chemoresistance is still a major cause of treatment failure. Hence, we develop a novel synthetic agent, COM33, to relieve the chemoresistance caused by carboplatin. The… read more here.
Keywords: com33 suppresses; carboplatin; ovarian cancer; carboplatin induced ... See more keywords