Carborane Analogues of Fenoprofen Exhibit Improved Antitumor Activity
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200583
Abstract: Fenoprofen is a widely used nonsteroidal anti‐inflammatory drug (NSAID) against rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Like other NSAIDs, fenoprofen inhibits the synthesis of prostaglandins by blocking both cyclooxygenase (COX) isoforms, COX‐1… read more here.
Keywords: analogues fenoprofen; antitumor; carborane analogues; exhibit improved ... See more keywords
Comparative study of the effects of ortho-, meta- and para-carboranes (C2B10H12) on the physicochemical properties, cytotoxicity and antiviral activity of uridine and 2'-deoxyuridine boron cluster conjugates.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103466
Abstract: In this study, a series of uridine (U) and 2'-deoxyuridine (dU) conjugates containing an isomeric ortho-, meta- or para-carborane cluster (C2B10H12) attached at C-5 through an ethynyl linker were synthesized. The effect of carborane cluster… read more here.
Keywords: uridine deoxyuridine; carborane; boron cluster; para ... See more keywords
Transition metal-induced B–H functionalization of o-carborane
Sign Up to like & getrecommendations! Published in 2019 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2017.11.006
Abstract: Abstract Transition metal-mediated B–H functionalization of carboranes has drawn increasing interests during the last two decades. This review describes how to incorporate B–H functionalization into the derivation of half-sandwich transition metal complexes containing o-carborane dichalcogenolates.… read more here.
Keywords: transition metal; carborane; metal; functionalization ... See more keywords
Poly(phenylene-carborane) grafted graphene oxide for lightweight and thin–thickness microwave absorption composites
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Alloys and Compounds"
DOI: 10.1016/j.jallcom.2021.158708
Abstract: Abstract The poly(phenylene-carborane) (PPB) is covalently attached to the surface of graphene oxide (GO) for the first time via Ni(0)-catalyzed polymerization, and the functionalization of the GO has been confirmed by XPS, XRD, FT-IR, SEM,… read more here.
Keywords: carborane; phenylene carborane; ppb; thickness ... See more keywords
Synthesis, structure and reactivity of a carborane-fused silylene 1-{[PhC(NtBu)2]Si}-1,2-C2B10H11
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2018.02.047
Abstract: Abstract A carborane-fused silylene 1-{[PhC(NtBu)2]Si}-1,2-C2B10H11 (2) has been prepared and structurally characterized from an equimolar reaction of 1-Li-1,2-C2B10H11 with [PhC(NtBu)2]SiCl (1) in Et2O. The reactions of 2 with elemental sulfur and benzophenone afforded the corresponding… read more here.
Keywords: phc ntbu; carborane fused; fused silylene; carborane ... See more keywords
Closo- or Nido-Carborane Diphosphane as Responsible for Strong Thermochromism or Time Activated Delayed Fluorescence (TADF) in [Cu(N^N)(P^P)]0/.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.1c03092
Abstract: Ortho-closo or ortho-nido-carborane-diphosphanes have been selected to prepare the heteroleptic cationic or neutral [Cu(N^N){(PPh2)2C2B10H10}]PF6 (1) and [Cu(N^N){(PPh2)2C2B9H10}] (2) [N^N = 2-(4-thiazolyl)benzimidazole], respectively. Complexes 1 and 2 display very different emissive behavior. Neutral complex 2 exhibits… read more here.
Keywords: time activated; delayed fluorescence; nido carborane; activated delayed ... See more keywords
Molecular Dynamics Simulation of Cyclooxygenase-2 Complexes with Indomethacin closo-Carborane Analogs
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00275
Abstract: Molecular dynamics simulation of carborane-containing ligands in complex with target enzymes is a challenging task due to the unique structure and properties of the carborane substituents and relative lack of appropriate experimental data to help… read more here.
Keywords: cyclooxygenase; molecular dynamics; carborane force; carborane ... See more keywords
Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00195
Abstract: The development of cannabinoid receptor type 2 (CB2R) radioligands for positron emission tomography (PET) imaging was intensively explored. To overcome the low metabolic stability and simultaneously increase the binding affinity of known CB2R radioligands, a… read more here.
Keywords: luz5; affinity; 18f luz5; pet ... See more keywords
Synthesis of o-Carborane-Fused Pyrazoles through Sequential C-N Bond Formation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01232
Abstract: Transition-metal-free synthetic method for o-carborane-fused pyrazoles as a new scaffold has been developed from the reaction of B(4)-acylmethyl or B(3,5)-diacylmethyl o-carborane with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP) in the presence of DBU in acetonitrile through sequential diazotization… read more here.
Keywords: fused pyrazoles; carborane fused; bond formation; carborane ... See more keywords
Flexible and Transparent Oligothiophene-o-Carborane-Containing Hybrid Films for Nonlinear Optical Limiting Based on Efficient Two-Photon Absorption.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c07835
Abstract: Structure-property relationship for fluorophores with favorable nonlinear optical (NLO) properties are promising topics in organic chemistry and material science. Herein, a series of terthiophene-o-carborane dyads and triads covalently linked with different end-capping styles were readily… read more here.
Keywords: two photon; photon absorption; carborane; optical limiting ... See more keywords
Facile Construction of New Hybrid Conjugation via Boron Cage Extension.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12526
Abstract: Aromatic polycyclic systems have been extensively utilized as structural subunits for the preparation of various functional molecules. Currently, aromatics-based polycyclic systems are predominantly generated from the extension of two-dimensional (2D) aromatic rings. In contrast, polycyclic… read more here.
Keywords: extension; new hybrid; construction new; carborane ... See more keywords