Synthesis, Characterization, and Investigation of Thermosensitive Star-Shaped Poly(2-isopropyl-2-oxazolines) Based on Carbosilane Dendrimers
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular Chemistry and Physics"
DOI: 10.1002/macp.201600387
Abstract: tar-shaped poly(2-isopropyl-2-oxazolines) with dramatically hydrophobic dendrimer core are synthesized using carbosilane dendrimers of first to third generations as macroinitiators. It is observed that half of the initiator functional groups are incorporated in polymerization process. The… read more here.
Keywords: carbosilane dendrimers; shaped poly; poly isopropyl; isopropyl oxazolines ... See more keywords
Efficacy of carbosilane dendrimers with an antiretroviral combination against HIV-1 in the presence of semen-derived enhancer of viral infection.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2017.05.060
Abstract: Amyloid fibrils, which are present in semen, were considered to be a cause of topical vaginal gel ineffectiveness in vivo after microbicides failed as HIV-1 prophylaxis. Therefore, it was necessary to determine whether a dendrimer… read more here.
Keywords: presence; hiv; viral infection; presence semen ... See more keywords
Carbosilane dendrimers with phosphonium terminal groups are low toxic non-viral transfection vectors for siRNA cell delivery.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.03.018
Abstract: Non-viral gene delivery vectors studied in the gene therapy applications are often designed with the cationic nitrogen containing groups necessary for binding and cell release of nucleic acids. Disadvantage is a relatively high toxicity which… read more here.
Keywords: non viral; delivery; gene; cell ... See more keywords
Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells
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DOI: 10.3390/pharmaceutics11010025
Abstract: This paper examines the complexation of anti-cancer small interfering RNAs (siRNAs) by cationic carbosilane dendrimers, and the interaction of the formed complexes with HeLa and HL-60 cancer cells. Stepwise formation of the complexes accompanied by… read more here.
Keywords: pro apoptotic; complexes pro; cancer cells; cancer ... See more keywords
Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14030536
Abstract: Infections caused by viruses from the Herpesviridae family produce some of the most prevalent transmitted diseases in the world, constituting a serious global public health issue. Some of the virus properties such as latency and… read more here.
Keywords: carbosilane; pegylated carbosilane; infection; carbosilane dendrimers ... See more keywords