5,6-Dihydropyrimidine-1(2H)-carbothioamides: Synthesis, in vitro GABA-AT screening, anticonvulsant activity and molecular modelling study.
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DOI: 10.1016/j.bioorg.2017.12.031
Abstract: Even after considerable advances in the field of epilepsy treatment, convulsions are inefficiently controlled by standard drug therapy. Herein, a series of pyrimidine-carbothioamide derivatives 4(a-t) was designed as anticonvulsant agents by doing some important structural… read more here.
Keywords: carbothioamides synthesis; study; synthesis vitro; vitro gaba ... See more keywords