Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105026
Abstract: In this work, two series of cyclic amine-containing benzimidazole carboxamide derivatives were designed and synthesized as potent anticancer agents. PARP1/2 inhibitory activity assays indicated that most of the compounds showed significant activity. The in vitro… read more here.
Keywords: piperidin benzo; imidazole carboxamide; carboxamide; benzo imidazole ... See more keywords
Carboxamide derivatives as new corrosion inhibitors for mild steel protection in hydrochloric acid solution
Sign Up to like & getrecommendations! Published in 2019 at "Corrosion Science"
DOI: 10.1016/j.corsci.2019.02.019
Abstract: Abstract In this study, the inhibitive performance of carboxamide ligands, (N-(quinolin-8-yl) quinoline-2-carboxamide), Hqcq; and (N-(quinolin-7-yl) pyrazine-2-carboxamide), Hqpzc, was examined under steady condition in HCl solution at 25 °C for mild steel. These carboxamides were synthesized using… read more here.
Keywords: carboxamide derivatives; mild steel; corrosion; carboxamide ... See more keywords
Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor Positive Allosteric Modulators with Enhanced Drug-Like Properties.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01953
Abstract: Targeting the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) allosteric site to potentiate endogenous 5-HT tone may provide novel therapeutics to alleviate the impact of costly, chronic diseases such as obesity and substance use disorders. Expanding upon… read more here.
Keywords: carboxamide; serotonin ht2c; allosteric modulators; ht2c receptor ... See more keywords
Catalyst-controlled directing group translocation in the site selective C–H functionalization of 3-carboxamide indoles and metallocarbenes
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-024-55246-2
Abstract: Complementary methods toward the selective functionalization of indole and oxindole frameworks employing an alternative strategy in heteroaryl C–H functionalizations are presented herein. This work focuses on a catalyst-controlled, site selective C–H activation/functionalization of 3-acyl indoles,… read more here.
Keywords: catalyst; carboxamide; functionalization; site ... See more keywords
A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46312-7
Abstract: Rings or arcs of fungus-regulated plant growth occurring on the floor of woodlands and grasslands are commonly called “fairy rings”. Fairy chemicals, 2-azahypoxanthine (AHX), imidazole-4-carboxamide (ICA), and 2-aza-8-oxohypoxanthine (AOH), are plant growth regulators involved in… read more here.
Keywords: carboxamide; metabolic pathway; rice; purine metabolic ... See more keywords
Control of Botrytis cinerea from Chilean grapevines by pydiflumetofen: baseline and carboxamide-mutant sensitivity.
Sign Up to like & getrecommendations! Published in 2024 at "Plant disease"
DOI: 10.1094/pdis-06-24-1338-re
Abstract: The gray mold (Botrytis cinerea; Botrytis) is the main disease affecting grapevines production in Chile. Succinate Dehydrogenase Inhibitors (SDHI) belonging to the carboxamides fungicide family are a key tool for the control of Botrytis in… read more here.
Keywords: control; control botrytis; carboxamide; sensitivity ... See more keywords
Design and Synthesis of Benzimidazole Carboxamide Cysteine Protease Inhibitors as Promising Anti-leishmanial Agents.
Sign Up to like & getrecommendations! Published in 2024 at "Current medicinal chemistry"
DOI: 10.2174/0109298673310232240910062647
Abstract: INTRODUCTION More than 20 protozoan species of Leishmania are responsible for causing Leishmaniasis, an infection spread by blood-feeding phlebotomine sandflies. A narrow pool of drugs is currently available rendering the current drug stratagem to treat… read more here.
Keywords: carboxamide; cysteine protease; protease; design synthesis ... See more keywords
Consensus-Based Pharmacophore Mapping for New Set of N-(disubstituted-phenyl)-3-hydroxyl-naphthalene-2-carboxamides
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21186583
Abstract: A series of twenty-two novel N-(disubstituted-phenyl)-3-hydroxynaphthalene- 2-carboxamide derivatives was synthesized and characterized as potential antimicrobial agents. N-[3,5-bis(trifluoromethyl)phenyl]- and N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxy- naphthalene-2-carboxamide showed submicromolar (MICs 0.16–0.68 µM) activity against methicillin-resistant Staphylococcus aureus isolates. N-[3,5-bis(trifluoromethyl)phenyl]- and N-[4-bromo-3-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide revealed… read more here.
Keywords: trifluoromethyl phenyl; activity; carboxamide; disubstituted phenyl ... See more keywords
Novel Coumarin 7-Carboxamide/Sulfonamide Derivatives as Potential Fungicidal Agents: Design, Synthesis, and Biological Evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27206904
Abstract: Coumarin compounds have a variety of biological activities such as anti-tumor, anti-coagulation, anti-HIV, anti-fungal, and insecticidal. Amide and sulfonamide compounds have been used as fungicides for half a century, and dozens of varieties have been… read more here.
Keywords: carboxamide sulfonamide; sulfonamide derivatives; carboxamide; coumarin carboxamide ... See more keywords