Study on synthesis and biological effects of a series of 3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2261-2
Abstract: In this paper, we have reported the synthesis and biological evaluation of nineteen (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives as novel candidate antidepressant and anticonvulsant agents. Compounds 2h, 2k, 2r, and 2s exhibited better potent antidepressant activity and displayed… read more here.
Keywords: carboxamide derivatives; study synthesis; dihydroisoquinoline carboxamide; synthesis biological ... See more keywords
Carboxamide derivatives as new corrosion inhibitors for mild steel protection in hydrochloric acid solution
Sign Up to like & getrecommendations! Published in 2019 at "Corrosion Science"
DOI: 10.1016/j.corsci.2019.02.019
Abstract: Abstract In this study, the inhibitive performance of carboxamide ligands, (N-(quinolin-8-yl) quinoline-2-carboxamide), Hqcq; and (N-(quinolin-7-yl) pyrazine-2-carboxamide), Hqpzc, was examined under steady condition in HCl solution at 25 °C for mild steel. These carboxamides were synthesized using… read more here.
Keywords: carboxamide derivatives; mild steel; corrosion; carboxamide ... See more keywords
Synthesis and biological evaluation of dihydroquinoline carboxamide derivatives as anti-tubercular agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.046
Abstract: Sodium trifluoromethanesulfonate, and glacial acetic acid selectively catalyzed the synthesis of dihydroquinoline via Friedländer annulation. The synthesized dihydroquinoline analogues coupled with different amines by the use of coupling reagent gave dihydroquinoline carboxamide derivatives in moderate… read more here.
Keywords: carboxamide derivatives; anti tubercular; dihydroquinoline carboxamide; synthesis biological ... See more keywords
Novel coumarin-pyrazole carboxamide derivatives as potential topoisomerase II inhibitors: Design, synthesis and antibacterial activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.059
Abstract: The identification of novel Topoisomerase II (Topo II) inhibitors is one of the most attractive directions in the field of bactericide research and development. In our ongoing efforts to pursue the class of inhibitors, six… read more here.
Keywords: novel coumarin; carboxamide derivatives; pyrazole carboxamide; coumarin pyrazole ... See more keywords
Design, synthesis and biological evaluation of novel naphthoquinone-4-aminobenzensulfonamide/carboxamide derivatives as proteasome inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112890
Abstract: A series of novel 4-aminobenzensulfonamide/carboxamide derivatives bearing naphthoquinone pharmacophore were designed, sythesized and evaluated for their proteasome inhibitory and antiproliferative activities against human breast cancer cell line (MCF-7). The structures of the synthesized compounds were… read more here.
Keywords: design synthesis; carboxamide derivatives; aminobenzensulfonamide carboxamide; inhibitory activity ... See more keywords
Synthesis, Biological Evaluation, and 3D-QSAR Studies of N-(Substituted pyridine-4-yl)-1-(substituted phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxamide Derivatives as Potential Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c05702
Abstract: A series of new fungicides that can inhibit the succinate dehydrogenase (SDH) was classified and named as SDH inhibitors by the Fungicide Resistance Action Committee in 2009. To develop more potential SDH inhibitors, we designed… read more here.
Keywords: carboxamide derivatives; pyrazole carboxamide; trifluoromethyl pyrazole; substituted pyridine ... See more keywords
Discovery of N-arylsulfonyl-indole-2-carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors- Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00726
Abstract: Liver fructose-1,6-bisphosphatase (FBPase) is a key enzyme in the gluconeogenesis pathway. Inhibiting FBPase activity represents a potential treatment for type 2 diabetes mellitus. A series of novel N-arylsulfonyl-4-arylamino-indole-2-carboxamide derivatives have been disclosed as FBPase inhibitors.… read more here.
Keywords: carboxamide derivatives; indole carboxamide; ray crystal; fructose bisphosphatase ... See more keywords
Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists
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DOI: 10.1039/d1ra08867j
Abstract: TGR5 is emerging as an important and promising target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated in vitro… read more here.
Keywords: design synthesis; phenoxypyrazine carboxamide; evaluation phenoxypyrazine; carboxamide derivatives ... See more keywords
Metal-free 1,3-dipolar cyclization of azides with HFO-1233zd(E) under amine participation: one-step regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00333g
Abstract: A simple and metal-free strategy for regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives was developed by employing azides, HFO-1233zd (E) and amines in aqueous reaction medium. The defluorination functionalization of the... read more here.
Keywords: triazole carboxamide; substituted triazole; metal free; synthesis substituted ... See more keywords
Synthesis and preliminary evaluations of [18F]fluorinated pyridine-2-carboxamide derivatives for targeting PD-L1 in cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009623666221021121014
Abstract: BACKGROUND Treatment with immune checkpoint inhibitors has improved both progression-free survival and overall survival in a subset of patients with tumors. However, the selection of patients who benefit from immune checkpoint inhibitor treatment remains challenging.… read more here.
Keywords: 18f 18f; pyridine carboxamide; carboxamide derivatives; cancer ... See more keywords
Diarylamine-Guided Carboxamide Derivatives: Synthesis, Biological Evaluation, and Potential Mechanism of Action
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.953523
Abstract: Diarylamines are a class of important skeleton widely existing in drugs or natural products. To discover novel diarylamine analogues as potential drugs, two series of diamide and carboxamide derivatives containing diarylamine scaffold were designed, synthesized… read more here.
Keywords: synthesis biological; derivatives synthesis; diarylamine; diarylamine guided ... See more keywords