G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.03.004
Abstract: &NA; Smads (sma/mothers against decapentaplegic) are transcription factors, which can be phosphorylated in the carboxy terminal (pSmad2/3C) or in the structurally central linker region (pSmad2/3 L). Only receptor kinases such as Transforming Growth Factor (TGF)‐&bgr;… read more here.
Keywords: carboxy terminal; region phosphorylation; phosphorylation; linker region ... See more keywords
Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.12.001
Abstract: The major effect of allosteric HIV integrase (IN) inhibitors (ALLINIs) is observed during virion maturation, where ALLINI treatment interrupts IN-RNA interactions via drug-induced IN aggregation, leading to the formation of aberrant virions. To understand the… read more here.
Keywords: integrase inhibitors; carboxy terminal; formation; homomeric carboxy ... See more keywords
Interaction with the carboxy-terminal tip of SSB is critical for RecG function in E. coli
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad162
Abstract: Abstract In Escherichia coli, the single-stranded DNA-binding protein (SSB) acts as a genome maintenance organizational hub by interacting with multiple DNA metabolism proteins. Many SSB-interacting proteins (SIPs) form complexes with SSB by docking onto its… read more here.
Keywords: recg; dna; tip ssb; carboxy terminal ... See more keywords
EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky711
Abstract: Roberto Paredes1,2,†, Marion Schneider1,2,†, Adam Stevens2,3, Daniel J. White1,2, Andrew J. K. Williamson1,2, Joanne Muter1,2, Stella Pearson1,2, James R. Kelly1,2, Kathleen Connors1,2, Daniel H. Wiseman2,4, John A. Chadwick2,4, Harald Löffler5, Hsiang Ying Teng1,2, Simon Lovell2,6,… read more here.
Keywords: terminal phosphorylation; phosphorylation atm; carboxy terminal; atm mediated ... See more keywords
Mutation of the Carboxy-Terminal Processing Protease in Acinetobacter baumannii Affects Motility, Leads to Loss of Membrane Integrity, and Reduces Virulence
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9050322
Abstract: Motility plays an essential role in the host–parasite relationship of pathogenic bacteria, and is often associated with virulence. While many pathogenic bacteria use flagella for locomotion, Acinetobacter baumannii strains do not have flagella, but have… read more here.
Keywords: carboxy terminal; membrane integrity; processing protease; acinetobacter baumannii ... See more keywords
T Cell-Association of Carboxy-Terminal Dendrimers with Different Bound Numbers of Phenylalanine and Their Application to Drug Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15030888
Abstract: T cells play important roles in various immune reactions, and their activation is necessary for cancer immunotherapy. Previously, we showed that polyamidoamine (PAMAM) dendrimers modified with 1,2-cyclohexanedicarboxylic acid (CHex) and phenylalanine (Phe) underwent effective uptake… read more here.
Keywords: phe; terminal dendrimers; carboxy terminal; drug ... See more keywords