Process development for the total synthesis of the novel drug metabolite carboxy toremifene as a standard reference material along with characterization and purity assessment for the antidoping quality control purposes.
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DOI: 10.1002/dta.3387
Abstract: Tamoxifen and toremifene are two selective estrogen receptor modulators (SERMs) commonly used to treat breast cancer in women. Toremifene is well known as a triphenylethylene derivative. Carboxy toremifene is a common metabolite of toremifene and… read more here.
Keywords: toremifene; reference material; purity; carboxy toremifene ... See more keywords