Simultaneous 3-Nitrophenylhydrazine Derivatization Strategy of Carbonyl, Carboxyl and Phosphoryl Submetabolome for LC-MS/MS-Based Targeted Metabolomics with Improved Sensitivity and Coverage.
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DOI: 10.1021/acs.analchem.1c00767
Abstract: Metabolomics is a powerful and essential technology for profiling metabolic phenotypes and exploring metabolic reprogramming, which enables the identification of biomarkers and provides mechanistic insights into physiology and disease. However, its applications are still limited… read more here.
Keywords: derivatization strategy; sensitivity; carboxyl phosphoryl; derivatization ... See more keywords