Decreased UCHL1 expression as a cytologic biomarker for aggressive behavior in pancreatic neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2018 at "Surgery"
DOI: 10.1016/j.surg.2017.04.040
Abstract: Background. There are currently no reliable markers associated with aggressive behavior in well‐differentiated and moderately differentiated pancreatic neuroendocrine tumors. We aimed to determine whether expression of ubiquitin carboxyl‐terminal hydrolase L1 in conjunction with Ki67 can… read more here.
Keywords: aggressive behavior; pancreatic neuroendocrine; carboxyl terminal; ubiquitin carboxyl ... See more keywords
Ubiquitin Carboxyl Terminal Hydrolase L1 Attenuates TNF-α-Mediated Vascular Smooth Muscle Cell Migration Through Suppression of NF-κB Activation.
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DOI: 10.1536/ihj.17-541
Abstract: Ubiquitin carboxyl terminal hydrolase L1 (UCH-L1) is one of the deubiquitinating enzymes in the ubiquitin-proteasome system. It has been shown that UCH-L1 could markedly decrease neointima formation through suppressing vascular smooth muscle cell (VSMC) proliferation… read more here.
Keywords: cell migration; carboxyl terminal; ubiquitin carboxyl; migration ... See more keywords
Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure
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DOI: 10.3389/fcvm.2022.866901
Abstract: Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase known to play essential roles in the nervous tissue. Myocardial upregulation of UCHL1 was observed in human dilated cardiomyopathy and several animal models of heart disease, but… read more here.
Keywords: mice; terminal hydrolase; heart; ubiquitin carboxyl ... See more keywords
The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes
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DOI: 10.7554/elife.88329
Abstract: Anti-apoptotic proteins such as BCL-XL promote cell survival by sequestering pro-apoptotic BCL-2 family members, an activity that frequently contributes to tumorigenesis. Thus, the development of small-molecule inhibitors for anti-apoptotic proteins, termed BH3-mimetics, is revolutionizing how… read more here.
Keywords: puma; bh3 mimetic; carboxyl terminal; anti apoptotic ... See more keywords