Nitrogen starvation–induced oxidative stress relieves PII-mediated inhibition of acetyl-CoA carboxylase (ACCase) activity and signals enhanced lipid synthesis in Synechococcus PCC 7942
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-020-02316-9
Abstract: The present study shows the existence of P II -acetyl-CoA carboxylase interaction in the cyanobacterium Synechococcus sp. PCC 7942 and the possible adverse impact of nitrogen starvation on this interaction. The in silico and in… read more here.
Keywords: carboxylase; acetyl coa; coa carboxylase; nitrogen starvation ... See more keywords
Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.05.013
Abstract: Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with… read more here.
Keywords: wields double; pyruvate carboxylase; carboxylase; carboxylase wields ... See more keywords
Targeted knockdown of ribulose-1, 5-bisphosphate carboxylase-oxygenase in rice mesophyll cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Plant Physiology"
DOI: 10.1016/j.jplph.2021.153395
Abstract: We generated antisense constructs targeting two of the five Rubisco small subunit genes (OsRBCS2 and 4) which account for between 30–40 % of the RBCS transcript abundance in leaf blades. The constructs were driven by… read more here.
Keywords: ribulose bisphosphate; carboxylase; mesophyll cells; targeted knockdown ... See more keywords
Directed Evolution of Propionyl-CoA Carboxylase for Succinate Biosynthesis.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2021.02.006
Abstract: Due to low carboxylase activity, CO2 biotransformation is challenging to achieve using natural CO2 fixation pathways. Liu et al. have improved the activity of propionyl-CoA carboxylase (PCC) 94-fold, enabling the efficient synthesis of succinate from… read more here.
Keywords: carboxylase; propionyl coa; coa; directed evolution ... See more keywords
A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Cell Discovery"
DOI: 10.1038/celldisc.2016.55
Abstract: Acetyl-CoA carboxylases (ACCs) are crucial metabolic enzymes and attractive targets for drug discovery. Eukaryotic acetyl-CoA carboxylases are 250 kDa single-chain, multi-domain enzymes and function as dimers and higher oligomers. Their catalytic activity is tightly regulated by… read more here.
Keywords: unified molecular; carboxylase; molecular mechanism; acetyl coa ... See more keywords
Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis
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DOI: 10.1128/mbio.03602-21
Abstract: If bacteria experience a starvation for potassium, by far the most abundant metal ion in every living cell, they have to activate high-affinity potassium transporters, switch off growth activities such as translation and transcription of… read more here.
Keywords: cyclic amp; bacillus subtilis; starvation; carboxylase ... See more keywords
Multiple Carboxylase Deficiency Organic Acidemia as a Cause of Infantile Seizures.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP"
DOI: 10.29271/jcpsp.2021.01.95
Abstract: Multiple carboxylase deficiency organic Acidemia is a rare inherited metabolic disorder. It is autosomal recessive disorder of two types: Holocarboxylase deficiency and Biotinidase deficiency. It is the metabolic disorder resulting from deficiency of biotin as… read more here.
Keywords: multiple carboxylase; organic acidemia; carboxylase; deficiency organic ... See more keywords
CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.966089
Abstract: Pyruvate carboxylase (PC) is an important anaplerotic enzyme that replenishes the tricarboxylic acid cycle (TCA) intermediates. It prevents the collapse of the TCA cycle upon its intermediates are removed during high anabolic demand. We have… read more here.
Keywords: growth; migration; cancer cell; carboxylase ... See more keywords