Genomic distribution of 5‐formylcytosine and 5‐carboxylcytosine in human preimplantation embryos
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DOI: 10.1002/mrd.23074
Abstract: 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) are derivatives of 5-methylcytosine (5mC). Sequential enzymatic oxidation of 5mC produces 5-hydroxymethylcytosine (5hmC), 5fC, and 5caC. Similarly to 5hmC, 5fC and 5caC serve as transient intermediates in active DNA demethylation… read more here.
Keywords: formylcytosine; carboxylcytosine; preimplantation embryos; genomic distribution ... See more keywords
Excision of 5-carboxylcytosine by Thymine DNA Glycosylase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.2210/pdb6u16/pdb
Abstract: 5-Methylcytosine (mC) is an epigenetic mark that is written by methyltransferases, erased through passive and active mechanisms, and impacts transcription, development, diseases including cancer, and aging. Active DNA demethylation involves TET-mediated stepwise oxidation of mC… read more here.
Keywords: carboxylcytosine; dna; thymine dna; excision ... See more keywords