A Space‐Dependent ‘Enzyme‐Substrate’ Type Probe based on ‘Carboxylesterase‐Amide Group’ for Ultrafast Fluorescent Imaging Orthotopic Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206681
Abstract: Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis remains a significant challenge due to complex physical environment. Human carboxylesterase (CE) is expected to be a potential biomarker of hepatocellular carcinoma (HCC) to… read more here.
Keywords: carboxylesterase; hepatocellular carcinoma; amide group; probe ... See more keywords
Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2017.10.014
Abstract: Carboxylesterases are well known for their role in the metabolism of xenobiotics. However, recent studies have also implicated carboxylesterases in regulating a number of physiological processes including metabolic homeostasis and macrophage development, underlying the need… read more here.
Keywords: hce1; amide based; development amide; carboxylesterase ... See more keywords
Catalytic hydrolysis mechanism of aminocarboxylester substrate by human carboxylesterase 1: A theoretical study on methylphenidate hydrolysis
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2021.113198
Abstract: Abstract Human carboxylesterase 1 (hCES1) is an important carboxylesterase responsible for the hydrolysis of various esters and amides, and plays very important roles in drug metabolism and pharmacokinetics. In this study, we investigated hCES1-catalyzed hydrolysis… read more here.
Keywords: human carboxylesterase; hydrolysis; carboxylesterase; methylphenidate ... See more keywords
Phosphorylated flavonoids as selective carboxylesterase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2019.01.020
Abstract: A series of phosphorylated flavonoids has been synthesized and evaluated in vitro for inhibitory activity against carboxylesterase, acetylcholinesterase and butyrylcholinesterase as well as for their cytotoxicity towards human adenocarcinoma A549 and human glioblastoma U251 cell… read more here.
Keywords: flavonoids selective; phosphorylated flavonoids; selective carboxylesterase; carboxylesterase ... See more keywords
Characterization of a novel hyper-thermostable and chlorpyrifos-hydrolyzing carboxylesterase EstC: A representative of the new esterase family XIX.
Sign Up to like & getrecommendations! Published in 2020 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2020.104704
Abstract: Carboxylesterases have widely been used in a series of industrial applications, especially, the detoxification of pesticide residues. In the present study, EstC, a novel carboxylesterase from Streptomyces lividans TK24, was successfully heterogeneously expressed, purified and… read more here.
Keywords: chlorpyrifos; activity; family xix; carboxylesterase ... See more keywords
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01391
Abstract: Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting the need to discover new small-molecule inhibitors. A crystallographic X-ray fragment… read more here.
Keywords: phenyl oxadiazol; wnt signaling; carboxylesterase; optimization ... See more keywords
Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01965
Abstract: Human carboxylesterase 2 (hCES2) converts anticancer prodrugs, such as irinotecan, into their active metabolites via phase I drug metabolism. Owing to interindividual variability, hCES2 serves as a predictive marker of patient response to hCES2-activated prodrug-based… read more here.
Keywords: two photon; carboxylesterase; activity; hces2 ... See more keywords
Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization
Sign Up to like & getrecommendations! Published in 2022 at "ACS Catalysis"
DOI: 10.1021/acscatal.2c03772
Abstract: TfCa, a promiscuous carboxylesterase from Thermobifida fusca, was found to hydrolyze polyethylene terephthalate (PET) degradation intermediates such as bis(2-hydroxyethyl) terephthalate (BHET) and mono-(2-hydroxyethyl)-terephthalate (MHET). In this study, we elucidated the structures of TfCa in its… read more here.
Keywords: insights tere; structural insights; terephthalate; carboxylesterase ... See more keywords
Selective detection of carboxylesterase 2 activity in cancer cells using an activity-based chemiluminescent probe.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03309g
Abstract: Carboxylesterase 2 (CES2) has crucial roles in both xenobiotic metabolism and formation of pathogenic states including cancer. Thus, it is highly critical to monitor intracellular CES2 activity in living cancer cells. Here, we report a… read more here.
Keywords: cancer cells; ces2; carboxylesterase; activity ... See more keywords
Evaluation on the Metabolic Activity of Two Carboxylesterase Isozymes in Mouse Liver Microsomes by a LC-MS/MS Method.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac105
Abstract: An applicable method for the precise measurement of major carboxylesterase (CESs) activity in liver still limited. Clopidogrel and irinotecan are specific substrates for CES1 and CES2, respectively. Clopidogrel is metabolized to the inactive metabolite clopidogrel… read more here.
Keywords: evaluation metabolic; mouse liver; liver microsomes; metabolic activity ... See more keywords
Molecular identification of carboxylesterase genes and their potential roles in the insecticides susceptibility of Grapholita molesta
Sign Up to like & getrecommendations! Published in 2023 at "Insect Molecular Biology"
DOI: 10.1111/imb.12831
Abstract: Grapholita molesta is one of the most damaging pests worldwide in stone and pome fruits. Application of chemical pesticides is still the main method to control this pest, which results in resistance to several types… read more here.
Keywords: grapholita molesta; insecticides susceptibility; carboxylesterase; susceptibility ... See more keywords