Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor.
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DOI: 10.1021/acs.orglett.8b01316
Abstract: A catalytic asymmetric [3 + 2] cyclization of novel 4-isothiocyanato pyrazolones and isatin-derived ketimines was developed, delivering a wide range of intriguing dispirotriheterocyclic products in high yield with excellent diastereoselectivity and enantioselectivity. A chiral sulfoxide… read more here.
Keywords: construction multi; asymmetric construction; carboxylesterase inhibitor; human carboxylesterase ... See more keywords