Synthesis, characterization and in vitro biological assays of copper(II) and nickel(II) complexes with furan‐2‐carboxylic acid hydrazide
Sign Up to like & getrecommendations! Published in 2017 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.3582
Abstract: Two transition metal complexes, [Cu(FH)3]⋅2Cl⋅2H2O and [Ni(FH)3]⋅2Cl⋅2H2O, were synthesized from the reactions of furan-2-carboxylic acid hydrazide with CuCl2⋅2H2O and NiCl2⋅6H2O. The synthesized complexes were characterized using analytical and various spectral techniques. The structures of the… read more here.
Keywords: showed complexes; carboxylic acid; acid hydrazide; furan carboxylic ... See more keywords
2‐Benzamido‐4‐methylthiazole‐5‐carboxylic Acid Derivatives as Potential Xanthine Oxidase Inhibitors and Free Radical Scavengers
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201600313
Abstract: The new chemical entities febuxostat and topiroxostat have been approved by the US Food and Drug Administration, opening new avenues for exploiting different heterocycles other than purines as xanthine oxidase (XO) inhibitors. A different series… read more here.
Keywords: xanthine oxidase; carboxylic acid; benzamido methylthiazole; methylthiazole carboxylic ... See more keywords
Synthesis and biological evaluation of new quinoline‐4‐carboxylic acid‐chalcone hybrids as dihydroorotate dehydrogenase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200374
Abstract: Fourteen novel quinoline‐4‐carboxylic acid‐chalcone hybrids were obtained via Claisen–Schmidt condensation and evaluated as potential human dihydroorotate dehydrogenase (hDHODH) inhibitors. The ketone precursor 2 was synthesized by the Pfitzinger reaction and used for further derivatization at… read more here.
Keywords: carboxylic acid; acid chalcone; chalcone hybrids; dihydroorotate dehydrogenase ... See more keywords
Virtual screening of carboxylic acid reductases for biocatalytic synthesis of 6-aminocaproic acid and 1,6-hexamethylenediamine.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28408
Abstract: The key precursors for nylon synthesis, that is, 6-aminocaproic acid (6-ACA) and 1,6-hexamethylenediamine (HMD), are produced from petroleum-based feedstocks. A sustainable biocatalytic alternative method from bio-based adipic acid has been demonstrated recently. However, the low… read more here.
Keywords: carboxylic acid; synthesis aminocaproic; virtual screening; acid ... See more keywords
Palladium/Carboxylic Acid‐catalyzed Alkenylation of Furfural and its Derivatives Using Alkynes
Sign Up to like & getrecommendations! Published in 2020 at "ChemCatChem"
DOI: 10.1002/cctc.202001685
Abstract: Furfural and its derivatives underwent alkenylation with alkynes via α‐C−H activation in the presence of a palladium/carboxylic acid catalyst to give the corresponding single and double alkenylated products. The reactive aldehyde group remained intact during… read more here.
Keywords: carboxylic acid; acid catalyzed; furfural derivatives; palladium carboxylic ... See more keywords
Whole-cell biocatalytic of Bacillus cereus WZZ006 strain to synthesis of indoxacarb intermediate: (S)-5-Chloro-1-oxo-2,3-dihydro-2-hydroxy-1H-indene-2-carboxylic acid methyl ester.
Sign Up to like & getrecommendations! Published in 2019 at "Chirality"
DOI: 10.1002/chir.23124
Abstract: In this study, a newly isolated strain screened from the indoxacarb-rich agricultural soils, Bacillus cereus WZZ006, has a high stereoselectivity to racemic substrate 5-chloro-1-oxo-2,3-dihydro-2-hydroxy-1H-indene-2-carboxylic acid methyl ester. (S)-5-chloro-1-oxo-2,3-dihydro-2-hydroxy-1H-indene-2-carboxylic acid methyl ester was obtained by bio-enzymatic… read more here.
Keywords: oxo dihydro; hydroxy indene; chloro oxo; indene carboxylic ... See more keywords
[Carboxyl‐11C]Labelling of Four High‐Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700697
Abstract: Cytosolic phospholipase A2α (cPLA2α) may play a critical role in neuropsychiatric and neurodegenerative disorders associated with oxidative stress and neuroinflammation. An effective PET radioligand for imaging cPLA2α in living brain might prove useful for biomedical… read more here.
Keywords: four high; indole carboxylic; cpla2; carboxylic acid ... See more keywords
Tetrazole as a Carboxylic Acid Isostere and the Synthesis of All Amine-Based Polyampholytes.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200096
Abstract: A new family of polyampholytes (PAMs) is described in which both the basic and acidic groups are based on nitrogen functional groups. RAFT-prepared poly(pentafluorophenyl acrylate) was quantitatively modified sequentially with 3-picolylamine and 5-aminotetrazole, yielding the… read more here.
Keywords: carboxylic acid; isostere synthesis; tetrazole carboxylic; amine based ... See more keywords
Engineering of a chromogenic enzyme screening system based on an auxiliary indole‐3‐carboxylic acid monooxygenase
Sign Up to like & getrecommendations! Published in 2019 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.795
Abstract: Here, we present a proof‐of‐principle for a new high‐throughput functional screening of metagenomic libraries for the selection of enzymes with different activities, predetermined by the substrate being used. By this approach, a total of 21… read more here.
Keywords: screening system; indole carboxylic; carboxylic acid; system based ... See more keywords
Electrochemical Detection of Dopamine using a Phenyl Carboxylic Acid‐Functionalized Electrode Made by Electrochemical Reduction of a Diazonium Salt
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DOI: 10.1002/open.202200233
Abstract: Abstract A glassy carbon electrode (GCE) has been modified by an in situ electrochemical reduction of an aryldiazonium salt generated from the reaction of 4‐aminobenzoic acid and sodium nitrite in acidic ethanolic solution. The as‐prepared phenyl… read more here.
Keywords: carboxylic acid; phenyl carboxylic; dopamine; electrochemical reduction ... See more keywords
Pyrazole amino acids: hydrogen bonding directed conformations of 3‐amino‐1H‐pyrazole‐5‐carboxylic acid residue
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Peptide Science"
DOI: 10.1002/psc.3018
Abstract: A series of model compounds containing 3‐amino‐1H‐pyrazole‐5‐carboxylic acid residue with N‐terminal amide/urethane and C‐terminal amide/hydrazide/ester groups were investigated by using NMR, Fourier transform infrared, and single‐crystal X‐ray diffraction methods, additionally supported by theoretical calculations. The… read more here.
Keywords: acid residue; amino pyrazole; pyrazole carboxylic; carboxylic acid ... See more keywords