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   Articles with "carboxypeptidase" as a keyword



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Structure of Aedes aegypti carboxypeptidase B1‐inhibitor complex uncover the disparity between mosquito and non‐mosquito insect carboxypeptidase inhibition mechanism

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recommendations! Published in 2021 at "Protein Science"

DOI: 10.1002/pro.4212

Abstract: Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and development. MCPs are also part of the digestive system of plant‐feeding insects, representing key targets… read more here.

Keywords: mosquito; inhibitor; carboxypeptidase; non mosquito ... See more keywords
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Immobilization of Carboxypeptidase A into Modified Chitosan Matrixes by Covalent Attachment

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recommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"

DOI: 10.1007/s12010-018-2708-4

Abstract: Carboxypeptidase A (CPA) is a metalloexopeptidase that catalyzes the hydrolysis of the peptide bonds that are adjacent to the C-terminal end of a polypeptide chain. The enzyme preferentially cleaves over C-terminal L-amino acids with aromatic… read more here.

Keywords: chitosan matrixes; immobilization carboxypeptidase; immobilization; carboxypeptidase ... See more keywords
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Insight into the transition between the open and closed conformations of Thermus thermophilus carboxypeptidase.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.01.167

Abstract: Carboxypeptidase cleaves the C-terminal amino acid residue from proteins and peptides. Here, we report the functional and structural characterizations of carboxypeptidase belonging to the M32 family from the thermophilic bacterium Thermus thermophilus HB8 (TthCP). TthCP… read more here.

Keywords: open closed; carboxypeptidase; thermus thermophilus; closed states ... See more keywords
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Structure of the microbial carboxypeptidase T complexed with the transition state analog N-sulfamoyl-l-lysine.

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recommendations! Published in 2020 at "Biophysical chemistry"

DOI: 10.1016/j.bpc.2020.106535

Abstract: Carboxypeptidase T (CPT) from Thermoactinomyces vulgaris (EC 3.4.17.18) has a broad substrate specificity, the mechanism of which remains unclear. It cleaves off arginine residues by 10, and lysine residues by 100 times worse than hydrophobic… read more here.

Keywords: carboxypeptidase; sulfamoyl lysine; structure; analog sulfamoyl ... See more keywords
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Integrated roles of BclA and DD-carboxypeptidase 1 in Bradyrhizobium differentiation within NCR-producing and NCR-lacking root nodules

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-08830-0

Abstract: Legumes harbor in their symbiotic nodule organs nitrogen fixing rhizobium bacteria called bacteroids. Some legumes produce Nodule-specific Cysteine-Rich (NCR) peptides in the nodule cells to control the intracellular bacterial population. NCR peptides have antimicrobial activity… read more here.

Keywords: ncr peptides; carboxypeptidase; ncr producing; differentiation ... See more keywords
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A New Class of Cell Wall-Recycling l,d-Carboxypeptidase Determines β-Lactam Susceptibility and Morphogenesis in Acinetobacter baumannii

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recommendations! Published in 2021 at "mBio"

DOI: 10.1128/mbio.02786-21

Abstract: To grow efficiently, resist antibiotics, and control the immune response, bacteria recycle parts of their cell wall. A key step in the typical recycling pathway is the reuse of cell wall peptides by an enzyme… read more here.

Keywords: wall recycling; carboxypeptidase; cell wall; cell ... See more keywords
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Three-Dimensional Structure of a Mutant of Carboxypeptidase T from Thermoactinomyces vulgaris Bearing an Implanted S1' Subsite of Pancreatic Carboxypeptidase B Complexed with a Product Analog

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recommendations! Published in 2019 at "Crystallography Reports"

DOI: 10.1134/s1063774519040035

Abstract: A mutant of bacterial carboxypeptidase T from Thermoactinomyces vulgaris (CPT5) with amino-acid substitutions in the S1' specificity pocket of the active site for the residues corresponding to the S1' region of pancreatic carboxypeptidase B (Gly215Ser,… read more here.

Keywords: three dimensional; carboxypeptidase; carboxypeptidase thermoactinomyces; pancreatic carboxypeptidase ... See more keywords
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Study of the cwaRS-ldcA Operon Coding a Two-Component System and a Putative L,D-Carboxypeptidase in Lactobacillus paracasei

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recommendations! Published in 2020 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2020.00156

Abstract: The cell surface is the primary recognition site between the bacterium and the host. An operon of three genes, LSEI_0219 (cwaR), LSEI_0220 (cwaS), and LSEI_0221 (ldcA), has been previously identified as required for the establishment… read more here.

Keywords: component system; lactobacillus paracasei; carboxypeptidase; putative carboxypeptidase ... See more keywords
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Neurotrophic Factor-α1/Carboxypeptidase E Functions in Neuroprotection and Alleviates Depression

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recommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2022.918852

Abstract: Depression is a major psychiatric disease affecting all ages and is often co-morbid with neurodegeneration in the elderly. Depression and neurodegeneration are associated with decreased neurotrophic factors. In this mini-review the functions and potential therapeutic… read more here.

Keywords: neuroprotection; depression; factor; carboxypeptidase ... See more keywords
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Carboxypeptidase N2 as a Novel Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.843325

Abstract: Carboxypeptidase N2 (CPN2) is a plasma metallo-protease that cleaves basic amino acids from the C-terminal of peptides and proteins. Emerging evidence showed that carboxypeptidases perform many diverse functions in the body and play key roles… read more here.

Keywords: carboxypeptidase; cpn2; lung adenocarcinoma; expression ... See more keywords