Thresholds for Carcinogens.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109464
Abstract: Current regulatory cancer risk assessment principles and practices assume a linear dose-response relationship-the linear no-threshold (LNT) model-that theoretically estimates cancer risks occurring following low doses of carcinogens by linearly extrapolating downward from experimentally determined risks… read more here.
Keywords: latency; tumor incidence; tumor latency; cancer ... See more keywords
Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats
Sign Up to like & getrecommendations! Published in 2018 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2017.11.001
Abstract: Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the… read more here.
Keywords: stress hormones; induced cancer; normal microenvironment; cancer ... See more keywords
Priority Setting for Occupational Cancer Prevention
Sign Up to like & getrecommendations! Published in 2018 at "Safety and Health at Work"
DOI: 10.1016/j.shaw.2017.07.005
Abstract: Background Selecting priority occupational carcinogens is important for cancer prevention efforts; however, standardized selection methods are not available. The objective of this paper was to describe the methods used by CAREX Canada in 2015 to… read more here.
Keywords: cancer prevention; priority; occupational cancer; cancer ... See more keywords
In Vivo Stable-Isotope Labeling and Mass-Spectrometry-Based Metabolic Profiling of a Potent Tobacco-Specific Carcinogen in Rats.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01881
Abstract: The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a potent lung carcinogen that exerts its carcinogenic effects upon metabolic activation. The identification and quantitation of NNK metabolites could identify potential biomarkers of bioactivation and detoxification of this… read more here.
Keywords: isotope labeling; mass spectrometry; nnk metabolites; tobacco specific ... See more keywords
Early antitumor activity of oral Langerhans cells is compromised by a carcinogen
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118424119
Abstract: Significance Oral cancer is often diagnosed at late stages, resulting in a poor prognosis of this disease. Understanding early carcinogenic events taking place during the development of oral cancer is, therefore, an important unmet clinical… read more here.
Keywords: carcinogen; langerhans cells; oral cancer; compromised carcinogen ... See more keywords
The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz123
Abstract: Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the… read more here.
Keywords: adam17; induced lung; tobacco smoke; cancer ... See more keywords
Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.088351
Abstract: Menthol, which creates mint flavor and scent, is often added to tobacco in both menthol and nonmenthol cigarettes. A potent tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is extensively metabolized to its equally carcinogenic metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) as… read more here.
Keywords: tobacco; glucuronidation; nnal gluc; carcinogen ... See more keywords
Carcinogen sodium arsenite disrupts antioxidant and redox homeostasis in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2020-0235
Abstract: Abstract Objectives The inadvertent exposure to environmental contaminants has been reported to induce cancer in different animal models. Here, we investigated the toxicity of Sodium Arsenite (SA), a Class I Carcinogen in Drosophila melanogaster. Methods… read more here.
Keywords: sodium arsenite; drosophila melanogaster; carcinogen;
Cure or Carcinogen? A Framing Analysis of European Radon Spa Websites
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Public Health"
DOI: 10.3389/ijph.2022.1604559
Abstract: Objectives: Radon, a radioactive gas, is among the leading causes of lung-cancer worldwide. While public health authorities emphasize radon’s health risks, there are spas across Europe which claim health benefits of radon. This study investigates… read more here.
Keywords: carcinogen; health; public health; radon ... See more keywords
Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043676
Abstract: Cancer is one of the leading causes of death worldwide. Chemotherapy and radiation therapy are currently providing the basis for cancer therapies, although both are associated with significant side effects. Thus, cancer prevention through dietary… read more here.
Keywords: carcinogen; damage; dna damage; damage activation ... See more keywords
Substantial Evidences Indicate That Inorganic Arsenic Is a Genotoxic Carcinogen: a Review
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Research"
DOI: 10.5487/tr.2018.34.4.311
Abstract: Arsenic is one of the most toxic environmental toxicants. More than 150 million people worldwide are exposed to arsenic through ground water contamination. It is an exclusive human carcinogen. Although the hallmarks of arsenic toxicity… read more here.
Keywords: arsenic genotoxic; genotoxic carcinogen; inorganic arsenic; substantial evidences ... See more keywords