Computational characterization of domain-segregated 3D chromatin structure and segmented DNA methylation status in carcinogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13127
Abstract: The high-order chromatin structure, together with DNA methylation and other epigenetic marks, plays a vital role in gene regulation and displays abnormal status in cancer cells. Theoretical analyses are expected to provide a more unified… read more here.
Keywords: carcinogenesis; chromatin structure; dna methylation;
Tea bioactive components prevent carcinogenesis via anti‐pathogen, anti‐inflammation, and cell survival pathways
Sign Up to like & getrecommendations! Published in 2020 at "IUBMB Life"
DOI: 10.1002/iub.2445
Abstract: Cancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most… read more here.
Keywords: pathogen; anti pathogen; inflammation; tea ... See more keywords
Understanding the complicated relationship between antioxidants and carcinogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22643
Abstract: Reactive oxygen species (ROS) are generated as by‐product of cellular respiration and also due to the exposure of various xenobiotics, whereas mitochondrial electron transport chain is considered as the main source of ROS generation. The… read more here.
Keywords: antioxidants carcinogenesis; relationship antioxidants; understanding complicated; generation ... See more keywords
The diagnostic efficacy of circulating miRNAs in monitoring the early development of colitis‐induced colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28925
Abstract: Early detection of colorectal cancer and monitoring the progress in colon carcinogenesis stages is essential to reduce mortality. Therefore, there is continuous search for noninvasive biomarkers with high stability and good sensitivity and specificity. miRNAs… read more here.
Keywords: progress; circulating mirnas; mir; colorectal cancer ... See more keywords
Phosphorylated LASS2 inhibits prostate carcinogenesis via negative regulation of Wnt/β‐catenin signaling
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29926
Abstract: LASS2 is a novel tumor‐suppressor gene and has been characterized as a ceramide synthase, which synthesizes very‐long acyl chain ceramides. However, LASS2 function and pathway‐related activity in prostate carcinogenesis are still largely unexplored. Here, we… read more here.
Keywords: inhibits prostate; phosphorylated lass2; catenin; prostate carcinogenesis ... See more keywords
CBP‐triggered KDM2B acetylation accelerates the carcinogenesis of colon cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29196
Abstract: Lysine (K)‐specific demethylase 2B (KDM2B) has been testified to be an oncogene in diverse cancers, which joins in mediating the carcinogenesis of cancers. Nonetheless, the function of KDM2B in colon cancer remains unexplored. The study… read more here.
Keywords: kdm2b acetylation; colon cancer; acetylation; carcinogenesis ... See more keywords
Differential expression of LEF1/TCFs family members in colonic carcinogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22530
Abstract: Lef1/Tcfs family, which includes Lef1, Tcf1, Tcf3, and Tcf4, is required for the transcriptional activation induced by β‐catenin. However, whether all the members play the same role in colon carcinogenesis is not clear. We found… read more here.
Keywords: tcfs family; lef1 tcf1; tcf1; lef1 tcfs ... See more keywords
Prenatal arsenic exposure alters keratinocyte stem cell fate through persistent activation of IGF2R‐MAPK cascade leading to aggravated skin carcinogenesis in mice offspring
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23690
Abstract: Chronic exposure to arsenic (As) promotes skin carcinogenesis in humans and potentially disturbs resident stem cell dynamics, particularly during maternal and early life exposure. In the present study, we demonstrate how only prenatal arsenic exposure… read more here.
Keywords: stem cell; exposure; igf2r; carcinogenesis ... See more keywords
14‐3‐3σ/Stratifin and p21 limit AKT‐related malignant progression in skin carcinogenesis following MDM2‐associated p53 loss
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23771
Abstract: To study mechanisms driving/inhibiting skin carcinogenesis, stage‐specific expression of 14‐3‐3σ (Stratifin) was analyzed in skin carcinogenesis driven by activated rasHa/fos expression (HK1.ras/fos) and ablation of PTEN‐mediated AKT regulation (K14.creP/Δ5PTENflx/flx). Consistent with 14‐3‐3σ roles in epidermal… read more here.
Keywords: loss; basal; progression; carcinogenesis ... See more keywords
Precision therapy for cancer prevention by targeting carcinogenesis
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23798
Abstract: Cancer represents a major global public health burden, with new cases estimated to increase from 14 million in 2012 to 24 million by 2035. Primary prevention is an effective strategy to reduce the costs associated… read more here.
Keywords: cancer; carcinogenesis; prevention; cancer prevention ... See more keywords
Fascin protein stabilization by miR-146a implicated in the process of a chronic inflammation-related colon carcinogenesis model
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1175-2
Abstract: ObjectiveIn sporadic colon tumors, multistep process of well-known genetic alterations accelerates carcinogenesis; however, this does not appear to be the case in inflammation-related ones. We previously established a model of inflammation-related colon carcinogenesis using human… read more here.
Keywords: mir 146a; related colon; inflammation; colon ... See more keywords