Multi‐organ carcinogenicity by inhalation exposure to 2‐Bromopropane in rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Occupational Health"
DOI: 10.1002/1348-9585.12388
Abstract: Abstract Objective The purpose of this study was to investigate the carcinogenicity of 2‐bromopropane (2‐BP) in rats. Methods Male and female F344 rats were exposed by whole body inhalation to 2‐BP vapor at concentrations of… read more here.
Keywords: carcinogenicity; multi organ; gland; inhalation exposure ... See more keywords
Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22517
Abstract: Quantitative relationships between carcinogenic potency and mutagenic potency have been previously examined using a benchmark dose (BMD)‐based approach. We extended those analyses by using human exposure data for 48 compounds to calculate carcinogenicity‐derived and genotoxicity‐derived… read more here.
Keywords: carcinogenicity; response data; dose response; genotoxicity ... See more keywords
Hazard characterization of carcinogenicity, mutagenicity, and reproductive toxicity for short chain primary nitroalkanes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4169
Abstract: Nitroalkanes are organic aliphatic hydrocarbon compounds with a nitro moiety that are commonly used as solvents or intermediates to synthesize a variety of organic compounds due to their inherent reactivity. In June 2020, a harmonized… read more here.
Keywords: mutagenicity reproductive; toxicity; carcinogenicity mutagenicity; carcinogenicity ... See more keywords
Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2316-7
Abstract: Dammar resin is a natural food additive and flavoring substance present in many foods and drinks. The present study evaluates the chronic toxicity and carcinogenicity of dietary dammar resin in F344 rats. Dietary concentrations in… read more here.
Keywords: resin; f344 rats; toxicity; dammar resin ... See more keywords
In vivo carcinogenicity study of silver nanoparticles in transgenic rasH2 mice by one single-dose intravenous administration
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nanoparticle Research"
DOI: 10.1007/s11051-020-04836-4
Abstract: Benefited from their broad-spectrum antimicrobial property, silver nanoparticles (AgNPs) have been widely used in various daily life and medical products. Consequently, the bio-safety of AgNPs, especially long-term in vivo biological effects is of more and… read more here.
Keywords: silver nanoparticles; carcinogenicity study; mice; carcinogenicity ... See more keywords
Thiamethoxam induced hepatotoxicity and pro-carcinogenicity in rabbits via motivation of oxidative stress, inflammation, and anti-apoptotic pathway
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-0850-0
Abstract: Thiamethoxam (TMX) is a non-mutagenic neonicotinoid insecticide that is widely used to combat different types of insects. The hepatotoxicity and carcinogenicity of TMX have been approved previously in mice but not in rats. However, the… read more here.
Keywords: tmx; thiamethoxam; pro carcinogenic; carcinogenicity ... See more keywords
Clues to the non-carcinogenicity of certain N-Nitroso compounds: Role of alkylated DNA bases.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2020.106539
Abstract: N-Nitroso compounds (NOC) are known for the carcinogenicity of most members. However, 13% of 332 NOC reviewed in 1984 were found to be non-carcinogenic. The non-carcinogenicity of all N-nitrosamines with even one tertiary alkyl group… read more here.
Keywords: alkylated dna; nitroso compounds; base; dna bases ... See more keywords
Sources-specific carcinogenicity and mutagenicity of PM2.5-bound PAHs in Beijing, China: Variations of contributions under diverse anthropogenic activities.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.109552
Abstract: To study source-specific carcinogenicity and mutagenicity of polycyclic aromatic hydrocarbons (PAHs) under diverse anthropogenic activities, PM2.5-bound PAHs were detected in Beijing in four periods. PAHs in Asia-Pacific Economic Cooperation meeting (APEC) was much lower than… read more here.
Keywords: diverse anthropogenic; period; specific carcinogenicity; carcinogenicity mutagenicity ... See more keywords
Synthetic phenolic antioxidants: Metabolism, hazards and mechanism of action.
Sign Up to like & getrecommendations! Published in 2021 at "Food chemistry"
DOI: 10.1016/j.foodchem.2021.129488
Abstract: Synthetic phenolic antioxidants can interact with peroxides produced by food. This paper reviews correlation between BHA, BHT and TBHQ metabolism and harms they cause and provides a theoretical basis for rational use of BHA, BHT… read more here.
Keywords: synthetic phenolic; metabolism; bht; carcinogenicity ... See more keywords
An evaluation of carcinogenicity predictors from short-term and sub chronic repeat-dose studies of agrochemicals in rats: opportunities to refine and reduce animal use.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.08.003
Abstract: The aim of this study was to examine whether short term, repeat dose, rat studies provide sufficient information about potential carcinogenicity to enable predictions about the carcinogenic potential of agrochemicals to be made earlier in… read more here.
Keywords: inhibitor; pathology; day; carcinogenicity ... See more keywords
Carcinogenic risk of emerging persistent organic pollutant perfluorooctane sulfonate (PFOS): A proposal of classification
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2016.11.021
Abstract: Abstract Perfluoroalkyls are stable synthetic chemicals, able to repel oils, fats and water. These compounds have been used in the manufacturing of products such as Teflon®, lubricants, paints, fire‐fighting foams, coatings for pans, carpets, clothes,… read more here.
Keywords: risk; pfos; cancer risk; proposal ... See more keywords