Force-dependent extracellular matrix remodeling by early-stage cancer cells alters diffusion and induces carcinoma-associated fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119756
Abstract: It is known cancer cells secrete cytokines inducing normal fibroblasts (NFs) to become carcinoma-associated fibroblasts (CAFs). However, it is not clear how the CAF-promoting cytokines can effectively navigate the dense ECM, a diffusion barrier, in… read more here.
Keywords: diffusion; caf; associated fibroblasts; carcinoma associated ... See more keywords
Synchronic renal cell carcinoma associated with fibromixoid sarcoma: A rare finding
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2020.02.051
Abstract: Highlights • Renal cell carcinoma can be associated with other tumors.• Its association with fibromixoid sarcoma is rare.• We report a case of the aforementioned association.• Nephrectomy and removal of the fibromixoid sarcoma was done.•… read more here.
Keywords: sarcoma; renal cell; sarcoma rare; cell carcinoma ... See more keywords
The long noncoding RNA noncoding RNA activated by DNA damage (NORAD)-microRNA-496-Interleukin-33 axis affects carcinoma-associated fibroblasts-mediated gastric cancer development
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.2009412
Abstract: ABSTRACT Carcinoma-associated fibroblasts (CAFs) are one of the crucial parts of in the tumor microenvironment and contribute to tumor progression. Interleukin-33 (IL-33), a tissue-derived nuclear cytokine from the IL-1 family, has been found abnormally expressed… read more here.
Keywords: carcinoma associated; noncoding rna; cafs; associated fibroblasts ... See more keywords
Carcinoma-Associated Mesenchymal Stem/Stromal Cells: Architects of the Pro-tumorigenic Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac036
Abstract: Abstract The interaction between tumor cells and non-malignant hosts cells within the tumor microenvironment (TME) is critical to the pathophysiology of cancer. These non-malignant host cells, consisting of a variety of stromal, immune, and endothelial… read more here.
Keywords: carcinoma associated; mesenchymal stem; stem stromal; stem ... See more keywords
Sarcomatoid carcinoma associated with chronic empyema and early lung and pleural metastases
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000025692
Abstract: Abstract Introduction: The relationship between chronic empyema and malignant tumors, most of which are lymphoma, has been recognized for many decades. Sarcomatoid carcinoma associated with chronic empyema is extremely rare, may metastasize to other organs… read more here.
Keywords: chronic empyema; associated chronic; carcinoma associated; sarcomatoid carcinoma ... See more keywords
PO-328 Stemness features of prostate cancer cells induced by carcinoma-associated fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.841
Abstract: Introduction Carcinoma-associated fibroblasts (CAFs) play a key role during cancer progression through several mechanisms including the induction of the epithelial-mesenchymal transition (EMT) program, giving cancer cells the ability to initiate metastasis. As the cells progress… read more here.
Keywords: stemness features; associated fibroblasts; carcinoma associated; prostate cancer ... See more keywords
A Reflection on How Carcinoma-Associated Fibroblasts Were Recognized as Active Participants of Epithelial Tumorigenesis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-2553
Abstract: Today's view of cancer as a systemic disease was facilitated by studies accentuating the local as well as the systemic role that non-tumorigenic cells, such as carcinoma-associated fibroblasts, play in cancer onset, development, and progression.… read more here.
Keywords: tumorigenesis; cancer research; associated fibroblasts; carcinoma associated ... See more keywords
Metastatic Breast Carcinoma–Associated Fibroblasts Have Enhanced Protumorigenic Properties Related to Increased IGF2 Expression
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1268
Abstract: Purpose: The microenvironment of metastatic breast cancer is incompletely characterized, despite prior evidence that it plays a key role in the biology of metastasis. A major component of the tumor stroma is the carcinoma-associated fibroblast… read more here.
Keywords: expression; growth; carcinoma associated; cancer ... See more keywords
Abstract B007: Stemness features of prostate cancer cells induced by carcinoma-associated fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2017-b007
Abstract: Introduction: Carcinoma-associated fibroblasts (CAFs) play a key role during cancer progression through several mechanisms, including the induction of the epithelial-mesenchymal transition (EMT) program, giving cancer cells the ability to initiate metastasis. As the cells progress… read more here.
Keywords: stemness features; associated fibroblasts; carcinoma associated; prostate cancer ... See more keywords
Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1484
Abstract: The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a significant accumulation of fibroblasts as part of the host response to cancer. Employing single-cell RNA-sequencing, multiplex immunostaining, and several genetic mouse models, we identify carcinoma-associated… read more here.
Keywords: cafs; functional heterogeneity; carcinoma associated; associated fibroblasts ... See more keywords
Malignant ascites-derived exosomes promote proliferation and induce carcinoma-associated fibroblasts transition in peritoneal mesothelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15040
Abstract: Malignant ascites-derived exosomes have been demonstrated to participate in tumor metastasis. In peritoneal metastasis, normal mesothelial cells (MCs) can be converted into carcinoma-associated fibroblasts (CAFs) by mesothelial-mesenchymal transition (MMT). Herein, we evaluated the effect of… read more here.
Keywords: malignant ascites; associated fibroblasts; carcinoma associated; mesothelial cells ... See more keywords