In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo‐japonicum Imazeki, against human colonic carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2013
Abstract: Ganoderma neo‐japonicum is a well‐known medicinal mushroom in Asian countries. However, scientific validations on its curative activities are confined to cirrhosis and diabetes. In this study, the anticancer properties of G. neo‐japonicum were evaluated using… read more here.
Keywords: ganoderma neo; colonic carcinoma; neo japonicum; japonicum ... See more keywords
Dithionated Nucleobases as Effective Photodynamic Agents against Human Epidermoid Carcinoma Cells
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DOI: 10.1002/cmdc.201800148
Abstract: Sulfur‐substituted nucleobases (i.e., thiobases) are a prospective class of compounds for clinical and cosmetic topical phototherapies. Recent investigations of several thiobases have revealed the ultrafast and efficient population of reactive triplet states upon ultraviolet‐A (UVA)… read more here.
Keywords: human epidermoid; photodynamic agents; dithionated nucleobases; epidermoid carcinoma ... See more keywords
Impaired actin filaments decrease cisplatin sensitivity via dysfunction of volume‐sensitive Cl− channels in human epidermoid carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29767
Abstract: Cisplatin is a widely used platinum‐based anticancer drug in the chemotherapy of numerous human cancers. However, cancer cells acquire resistance to cisplatin. So far, functional loss of volume‐sensitive outwardly rectifying (VSOR) Cl− channels has been… read more here.
Keywords: human epidermoid; volume; cisplatin; epidermoid carcinoma ... See more keywords
GDF11 restricts aberrant lipogenesis and changes in mitochondrial structure and function in human hepatocellular carcinoma cells
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DOI: 10.1002/jcp.30151
Abstract: Growth differentiation factor 11 (GDF11) has been characterized as a key regulator of differentiation in cells that retain stemness features. Recently, it has been reported that GDF11 exerts tumor‐suppressive properties in hepatocellular carcinoma cells, decreasing… read more here.
Keywords: hepatocellular carcinoma; gdf11 restricts; carcinoma cells; gdf11 ... See more keywords
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23834
Abstract: Diallyl sulfide (DAS), as a major component of garlic extracts, has been shown to inhibit growth of hepatocellular carcinoma cells (HCC), but the underlying mechanism is still elusive. In this study, we aimed to explore… read more here.
Keywords: hepatocellular carcinoma; inhibition; growth; carcinoma cells ... See more keywords
The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2229-5
Abstract: Novel therapies are required for the treatment of metastatic renal cell carcinoma (RCC), which is associated with inoperable disease and patient death. Histone deacetylases (HDACs) are epigenetic modifiers and potential drug targets. Additional information on… read more here.
Keywords: carcinoma; deacetylases hdac1; histone deacetylases; renal carcinoma ... See more keywords
JS-K, a GST-activated nitric oxide donor prodrug, enhances chemo-sensitivity in renal carcinoma cells and prevents cardiac myocytes toxicity induced by Doxorubicin
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3359-9
Abstract: PurposeDoxorubicin, a highly effective and widely used anthracycline antibiotic in multiple chemotherapy regimens, has been limited by its cardiotoxicity. The aim of this study is to investigate the effect of nitric oxide donor prodrug JS-K… read more here.
Keywords: cardiac myocytes; carcinoma; apoptosis; toxicity ... See more keywords
(+)-Usnic acid modulates the Nrf2-ARE pathway in FaDu hypopharyngeal carcinoma cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-021-04092-7
Abstract: Naturally occurring phytochemicals of different origin and structure, arctigenin, bergenin, usnic acid and xanthohumol, were shown to affect Nrf2 pathway in the context of various diseases, but their effect on this pathway in cancer cells… read more here.
Keywords: nrf2 pathway; usnic acid; fadu hypopharyngeal; carcinoma cells ... See more keywords
Synthesis of steroid analogs of tubuloclustin, their cytotoxicity and effect on microtubules of A549 carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-018-2123-6
Abstract: Synthesis of analogs of tubuloclustin (N-(7-adamant-2-yloxy-7-oxoheptanoyl)-N-deacetylcolchicine (1)) with the colchicine fragment replaced with 2-methoxyestradiol scaffold attached via phenolic hydroxy group was described. Esters 3a–c exhibit moderate cytotoxicity (EC50 = 5–6 μmol L–1) and exert a… read more here.
Keywords: microtubules a549; effect; carcinoma cells; analogs tubuloclustin ... See more keywords
Extracts of Celastrus Orbiculatus Inhibit Cancer Metastasis by Down-regulating Epithelial-Mesenchymal Transition in Hypoxia-Induced Human Hepatocellular Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-018-2562-9
Abstract: ObjectiveTo evaluate the effects of Celastrus Orbiculatus extracts (COE) on metastasis in hypoxia-induced hepatocellular carcinoma cells (HepG2) and to explore the underlying molecular mechanisms.MethodsThe effect of COE (160, 200 and 240 µ g/mL) on cell… read more here.
Keywords: hepatocellular carcinoma; metastasis; carcinoma cells; hypoxia ... See more keywords
Evodiamine in combination with histone deacetylase inhibitors has synergistic cytotoxicity in thyroid carcinoma cells
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DOI: 10.1007/s12020-019-01885-1
Abstract: PurposeThe impact of evodiamine in combination with histone deacetylase (HDAC) inhibitors on survival of thyroid carcinoma cells was identified.MethodsTPC-1 and SW1736 human thyroid carcinoma cells were used.ResultsAfter treatment with evodiamine and PXD101, cell viability, the… read more here.
Keywords: combination; thyroid carcinoma; percentage; carcinoma cells ... See more keywords