Multi-omic analysis in carcinoma of unknown primary (CUP): therapeutic impact of knowing the unknown.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13293
Abstract: Carcinoma of unknown primary (CUP) is a difficult-to-manage malignancy. Multi-omic profiles and treatment outcome versus degree of precision matching was assessed. Tumors underwent next-generation sequencing (NGS) [tissue and/or blood-derived cell-free DNA (cfDNA)]. Selected patients had… read more here.
Keywords: cup; unknown primary; multi omic; analysis ... See more keywords
Prognostic impact of copy number alterations and tumor mutational burden in carcinoma of unknown primary
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23047
Abstract: Chromosomal aberrations are known to drive metastatic spread, but their profile is still elusive in carcinoma of unknown primary (CUP). Therefore, the aim of this study was to characterize the chromosomal aberration pattern in CUP… read more here.
Keywords: prognostic impact; unknown primary; tumor mutational; mutational burden ... See more keywords
Head and neck carcinoma of unknown primary.
Sign Up to like & getrecommendations! Published in 2019 at "European annals of otorhinolaryngology, head and neck diseases"
DOI: 10.1016/j.anorl.2019.04.002
Abstract: In adult cervicofacial pathology, carcinoma of unknown primary is defined as lymph-node metastasis the anatomic origin of which is not known at the time of initial management. It constitutes up to 5% of head and… read more here.
Keywords: carcinoma unknown; carcinoma; pathology; unknown primary ... See more keywords
Evaluation of Carcinoma of Unknown Primary on Cytologic Specimens.
Sign Up to like & getrecommendations! Published in 2018 at "Surgical pathology clinics"
DOI: 10.1016/j.path.2018.04.006
Abstract: Carcinoma of unknown primary is defined as metastatic carcinoma without a clinically obvious primary tumor. Determining the tissue of origin in carcinoma of unknown primary is important for site-directed therapy. Immunohistochemistry is the most widely… read more here.
Keywords: carcinoma unknown; carcinoma; evaluation carcinoma; unknown primary ... See more keywords
Adding cetuximab to paclitaxel and carboplatin for first-line treatment of carcinoma of unknown primary (CUP): results of the Phase 2 AIO trial PACET-CUP.
Sign Up to like & getrecommendations! Published in 2020 at "British journal of cancer"
DOI: 10.1038/s41416-020-01141-8
Abstract: BACKGROUND Patients with carcinoma of unknown primary (CUP) have a dismal prognosis, even when treated with multi-agent chemotherapy. We hypothesised that adding the epidermal growth-factor receptor (EGFR) inhibitor cetuximab to standard first-line chemotherapy with paclitaxel… read more here.
Keywords: paclitaxel carboplatin; carcinoma unknown; group; unknown primary ... See more keywords
Medullary thyroid carcinoma of unknown primary origin with synchronous finding of papillary thyroid carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Endokrynologia Polska"
DOI: 10.5603/ep.a2020.0003
Abstract: Synchronous existence of medullary and papillary thyroid carcinoma is an extremely rare occurrence; however, it has been previously reported. Nonetheless, such coexistence combined with the absence of primary tumor lesions of either of the two… read more here.
Keywords: carcinoma unknown; thyroid carcinoma; medullary thyroid; thyroid ... See more keywords