Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.04.024
Abstract: CARD8 detects intracellular danger signals and forms a caspase-1 activating inflammasome. Like the related inflammasome sensor NLRP1, CARD8 autoprocesses into noncovalently associated N-terminal (NT) and C-terminal (CT) fragments and binds the cellular dipeptidyl peptidases DPP8… read more here.
Keywords: sets threshold; card8; threshold card8; card8 inflammasome ... See more keywords
Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease
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DOI: 10.1172/jci98642
Abstract: In these studies, we evaluated the contribution of the NLRP3 inflammasome to Crohn’s disease (CD) in a kindred containing individuals having a missense mutation in CARD8, a protein known to inhibit this inflammasome. Whole exome… read more here.
Keywords: inflammasome activation; card8; card8 mutation; nlrp3 inflammasome ... See more keywords
The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1047922
Abstract: The NLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood. Here, we show that… read more here.
Keywords: card8; t60 variant; nlrp1 inflammasome; negatively regulates ... See more keywords