Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease
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DOI: 10.1172/jci98642
Abstract: In these studies, we evaluated the contribution of the NLRP3 inflammasome to Crohn’s disease (CD) in a kindred containing individuals having a missense mutation in CARD8, a protein known to inhibit this inflammasome. Whole exome… read more here.
Keywords: inflammasome activation; card8; card8 mutation; nlrp3 inflammasome ... See more keywords