Card9‐dependent IL‐1β regulates IL‐22 production from group 3 innate lymphoid cells and promotes colitis‐associated cancer
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646765
Abstract: Inflammatory bowel diseases (IBD) are key risk factors for the development of colorectal cancer, but the mechanisms that link intestinal inflammation with carcinogenesis are insufficiently understood. Card9 is a myeloid cell‐specific signaling protein that regulates… read more here.
Keywords: card9; production group; colitis associated; cancer ... See more keywords
Complete clinical remission of invasive Candida infection with CARD9 deficiency after G-CSF treatment.
Sign Up to like & getrecommendations! Published in 2020 at "Comparative immunology, microbiology and infectious diseases"
DOI: 10.1016/j.cimid.2020.101417
Abstract: Caspase-associated recruitment domain-containing protein 9 (CARD9) deficiency is an autosomal-recessive primary immunodeficiency characterized by susceptibility to recurrent Candida infections, and its diagnosis and treatment is challenging. The present study aims to investigate the genetic characteristic… read more here.
Keywords: card9; treatment; infection; candida ... See more keywords
CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2204015
Abstract: ABSTRACT Pancreatic cancer (PC) is featured with low survival rate and poor outcomes. Herein, we found that the expression of caspase-recruitment domain-containing protein 9 (CARD9), predominantly expressed in innate immune cells, was positively related to… read more here.
Keywords: maturation; card9; card9 deficiency; pancreatic cancer ... See more keywords
Contribution of CARD9‐mediated signalling to wound healing in skin
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13389
Abstract: The inflammatory response after skin injury involves the secretion of a variety of cytokines and growth factors that are necessary for tissue repair. Caspase recruitment domain‐containing protein 9 (CARD9) is an essential signalling adaptor molecule… read more here.
Keywords: mediated signalling; wound healing; card9; card9 mediated ... See more keywords
Dysregulated lipolysis and lipophagy in lipid droplets of macrophages from high fat diet‐fed obese mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17513
Abstract: Obesity is associated with lipid droplet (LD) accumulation, dysregulated lipolysis and chronic inflammation. Previously, the caspase recruitment domain‐containing protein 9 (CARD9) has been identified as a potential contributor to obesity‐associated abnormalities including cardiac dysfunction. In… read more here.
Keywords: inflammation; card9; obese mice; high fat ... See more keywords
CARD9 Is Required for Classical Macrophage Activation and the Induction of Protective Immunity against Pulmonary Cryptococcosis
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.03005-19
Abstract: Cryptococcus neoformans is a fungal pathogen that is found throughout the environment and can cause life-threatening infections of the lung and central nervous system in severely immunocompromised individuals. Caspase recruitment domain-containing protein 9 (CARD9) is… read more here.
Keywords: immunity neoformans; immunity; protective immunity; induction protective ... See more keywords
CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2022-326917
Abstract: Objectives Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflammation. Caspase recruitment domain 9… read more here.
Keywords: cell; role; card9; colitis ... See more keywords
CARD9 Signaling, Inflammation, and Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.880879
Abstract: Caspase-recruitment domain 9 (CARD9) protein is expressed in many cells especially in immune cells, and is critically involved in the function of the innate and adaptive immune systems through extensive interactions between CARD9 and other… read more here.
Keywords: signaling inflammation; card9; inflammation diseases; card9 signaling ... See more keywords
CARD9 in host immunity to fungal, bacterial, viral, and parasitic infections: An update
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1021837
Abstract: Microbial infection, caused by fungi, bacteria, viruses, and parasites, significantly contributes to the global death burden and health costs. The innate and adaptive immune systems orchestrate a multifaceted signaling response to invading pathogens as the… read more here.
Keywords: fungal bacterial; viral parasitic; card9; bacterial viral ... See more keywords
CARD9 Forms an Alternative CBM Complex in Richter Syndrome
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DOI: 10.3390/cancers14030531
Abstract: Simple Summary The transformation process of chronic lymphocytic leukemia into an aggressive lymphoma, called Richter syndrome (RS), is incompletely understood, and therapeutic options are limited. Here, we report CARD9 to be expressed in a subset… read more here.
Keywords: richter; card9; cell; richter syndrome ... See more keywords