Preclinical pharmacokinetics and ADME characterization of a novel anticancer chalcone, cardamonin.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2128
Abstract: Cardamonin (CRD), a chalconoid obtained from several medicinal plants of Zingiberaceae family, had shown promising potential in cancer prevention and therapy. For further development and better pharmacological elucidation, we performed a series of in vitro… read more here.
Keywords: cardamonin; characterization novel; preclinical pharmacokinetics; pharmacokinetics adme ... See more keywords
Cardamonin attenuates cerebral ischemia/reperfusion injury by activating the HIF‐1α/VEGFA pathway
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DOI: 10.1002/ptr.7409
Abstract: Cardamonin is a chalcone with neuroprotective activity. The aim of our study was to explore the functions and mechanism of action of cardamonin in ischemic stroke. Oxygen–glucose deprivation and reperfusion (OGD/R)‐induced human brain microvascular endothelial… read more here.
Keywords: brain; cardamonin; vegfa pathway; injury ... See more keywords
Cardamonin induces immune responses and enhances survival rate in WEHI‐3 cell–generated mouse leukemia in vivo
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DOI: 10.1002/tox.22881
Abstract: Cardamonin, a monomeric alkaloid, is isolated from Alpinia conchigera Griff and other natural plants. Recently, it has been focused on its anticancer activities, and no information showing its immune effects on leukemia mice was reported.… read more here.
Keywords: cardamonin; leukemia mice; cell; survival rate ... See more keywords
Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01986-z
Abstract: The antiproliferative effect of cardamonin on mTORC1 is related with downregulation of Raptor. We investigated the mechanism that cardamonin decreases Raptor expression through caspase-mediated protein degradation. SKOV3 cells and HeLa cells were pretreated with caspase… read more here.
Keywords: cardamonin; caspase; caspase mediated; cleavage ... See more keywords
Cardamonin, a natural chalcone, reduces 5-fluorouracil resistance of gastric cancer cells through targeting Wnt/β-catenin signal pathway
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DOI: 10.1007/s10637-019-00781-9
Abstract: Objectives Cardamonin (CD), an active chalconoid, has been extensively studied in a wide variety of human tumors. However, the effects and underlying mechanism of cardamonin on 5-fluorouracil (5-FU)-resistant gastric cancer (GC) remain largely unclear. This… read more here.
Keywords: cardamonin; gastric cancer; catenin; pathway ... See more keywords
Systematic screening and characterization of cardamonin metabolites using UHPLC-Q-Exactive Orbitrap MS after oral administration to rats
Sign Up to like & getrecommendations! Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2020.10.007
Abstract: Abstract Cardamonin is a chalcone that presents at high content in the seeds of Alpinia katsumadai Hayata. In recent decades, researchers have found that it is not only an edible spice, but also a remarkable… read more here.
Keywords: cardamonin; uhplc exactive; exactive orbitrap; oral administration ... See more keywords
Cardamonin protects against adverse cardiac remodeling through mTORC1 inhibition in mice with myocardial infarction.
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DOI: 10.1691/ph.2018.8600
Abstract: The mTORC1-dependent signaling pathway is mainly involved in the adverse left ventricular remodeling (ALVR) process after myocardial infarction (MI). However, whether mTORC1 inhibition by cardamonin attenuates ALVR after MI is still not reported. Twenty mice… read more here.
Keywords: cardamonin; myocardial infarction; mtorc1 inhibition; mice ... See more keywords
The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer’s Disease
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DOI: 10.3390/brainsci13010145
Abstract: Neurodegenerative diseases (ND) include a wide range of conditions that result from progressive damage to the neurons. Alzheimer’s disease (AD) is one of the most common NDs, and neuroinflammation and oxidative stress (OS) are the… read more here.
Keywords: therapeutic potential; neuroprotective effects; alzheimer disease; cardamonin ... See more keywords
Anti‑proliferative effect of cardamonin on mTOR inhibitor‑resistant cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular medicine reports"
DOI: 10.3892/mmr.2019.10898
Abstract: A number of mammalian target of rapamycin (mTOR) inhibitors have been approved for the treatment of certain types of cancer or are currently undergoing clinical trials. However, mTOR targeted therapy exerts selective pressure on tumour… read more here.
Keywords: cardamonin; mtor inhibitors; effect; mtor ... See more keywords