Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation
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DOI: 10.1093/hmg/ddy215
Abstract: Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart dysfunction in cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy). The mechanism of how this affects cardiac function is unknown. We show… read more here.
Keywords: cardiomyopathy caused; cofilin; cardiac actin; lamin gene ... See more keywords
Alpha-cardiac Actin Serum Expression Levels Detect Acute Cellular Rejection in Heart Transplant Patients
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DOI: 10.1097/tp.0000000000004273
Abstract: Background. Given the central role of sarcomeric dysfunction in cardiomyocyte biology and sarcomere alterations described in endomyocardial biopsies of transplant patients with rejection, we hypothesized that the serum expression levels of genes encoding sarcomeric proteins… read more here.
Keywords: alpha cardiac; expression levels; cardiac actin; serum expression ... See more keywords
Interrelation between α-Cardiac Actin Treadmilling and Myocardin-Related Transcription Factor-A Nuclear Shuttling in Cardiomyocytes
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DOI: 10.3390/ijms23137394
Abstract: Myocardin-related transcription factors (MRTFs) play a central role in the regulation of actin expression and cytoskeletal dynamics that are controlled by Rho GTPases. SRF is a ubiquitous transcription factor strongly expressed in muscular tissues. The… read more here.
Keywords: myocardin related; shuttling; actin; cardiac actin ... See more keywords