Cardiac aging and heart disease in humans
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0255-9
Abstract: The world population continues to grow older rapidly, mostly because of declining fertility and increasing longevity. Since age represents the largest risk factor for cardiovascular disease, the prevalence of these pathologies increases dramatically with increasing… read more here.
Keywords: cardiac aging; aging heart; age; heart disease ... See more keywords
TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04994-z
Abstract: Cellular senescence is a well-orchestrated programmed process involved in age-related pathologies, tumor suppression and embryonic development. TGF-β/Smad is one of the predominant pathways that regulate damage-induced and developmentally programmed senescence. Here we show that canonical… read more here.
Keywords: cardiac aging; senescence; via mir; cellular senescence ... See more keywords
P2254Impaired autophagic off-rate causes cardiac aging in progeria mouse model
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz748.0732
Abstract: Aging is known to be one of the primary causes of heart failure. Werner syndrome is one of the aging disorder that caused by dysfunction of DNA helicase-regulatory protein (WRN). However, there is little information… read more here.
Keywords: wrn; heart; cardiac aging; wrn k577m ... See more keywords
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging
Sign Up to like & getrecommendations! Published in 2022 at "Protein & Cell"
DOI: 10.1093/procel/pwac038
Abstract: Abstract Aging poses a major risk factor for cardiovascular diseases, the leading cause of death in the aged population. However, the cell type-specific changes underlying cardiac aging are far from being clear. Here, we performed… read more here.
Keywords: cell; single nucleus; primate cardiac; cardiac aging ... See more keywords
Expression patterns of cardiac aging in Drosophila
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12559
Abstract: Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age‐associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well‐suited to investigate the… read more here.
Keywords: heart; cardiac aging; expression patterns; patterns cardiac ... See more keywords
Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/9423593
Abstract: Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular diseases. Cardiac aging plays a central role in cardiovascular diseases. There is accumulating evidence linking cardiac aging to mtDNA damage, including mtDNA mutation and… read more here.
Keywords: mitochondrial ros; mtdna damage; cardiac aging; target ... See more keywords
Abstract 5759: Accelerated cardiac aging in adolescent and young adult cancer survivors previously treated with cardiotoxic therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5759
Abstract: Cancer in adolescents and young adults (AYA) is defined as cancer occurring between the ages of 15-39 years. Although cancer is the most common disease-related cause of death in this age group world-wide, the highly… read more here.
Keywords: cancer; aging adolescent; accelerated cardiac; cardiac aging ... See more keywords
Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging
Sign Up to like & getrecommendations! Published in 2021 at "Circulation"
DOI: 10.1161/circulationaha.121.054204
Abstract: Supplemental Digital Content is available in the text. Background: Aging myocardium undergoes progressive cardiac hypertrophy and interstitial fibrosis with diastolic and systolic dysfunction. Recent metabolomics studies shed light on amino acids in aging. The present… read more here.
Keywords: phenylalanine; role; cardiac aging; senescence ... See more keywords
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.127713
Abstract: The E3 ubiquitin ligase Parkin plays an important role in regulating clearance of dysfunctional or unwanted mitochondria in tissues, including the heart. However, whether Parkin also functions to prevent cardiac aging by maintaining a healthy… read more here.
Keywords: polg; cardiac aging; mice; mitochondrial dna ... See more keywords
Cisd2 is essential to delaying cardiac aging and to maintaining heart functions
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3000508
Abstract: CDGSH iron-sulfur domain-containing protein 2 (Cisd2) is pivotal to mitochondrial integrity and intracellular Ca2+ homeostasis. In the heart of Cisd2 knockout mice, Cisd2 deficiency causes intercalated disc defects and leads to degeneration of the mitochondria… read more here.
Keywords: heart; cisd2 essential; cardiac aging; cisd2 ... See more keywords
Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.840389
Abstract: Age-related alteration of mitochondria causes impaired cardiac function, along with cellular and molecular changes. Polyamines can extend the life span in mice. However, whether polyamines can affect the dynamic mitochondrial proteome, thereby preventing age-related changes… read more here.
Keywords: mitochondrial proteome; dynamic mitochondrial; polyamines treatment; cardiac aging ... See more keywords