Optimal control for nonlocal reaction‐diffusion system describing calcium dynamics in cardiac cell
Sign Up to like & getrecommendations! Published in 2020 at "Mathematical Methods in the Applied Sciences"
DOI: 10.1002/mma.7071
Abstract: The purpose of this paper is to introduce an optimal control for a nonlocal calcium dynamic model in a cardiac cell acting on ryanodine receptors. The optimal control problem is considered as a coupled nonlocal… read more here.
Keywords: optimal control; calcium; cardiac cell; nonlocal reaction ... See more keywords
On the Road to Regeneration: “Tools” and “Routes” Towards Efficient Cardiac Cell Therapy for Ischemic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "Current Cardiology Reports"
DOI: 10.1007/s11886-019-1226-5
Abstract: Cardiac regenerative medicine is a field bridging together biotechnology and surgical science. In this review, we present the explored surgical roads to cell delivery and the known effects of each delivery method on cell therapy… read more here.
Keywords: medicine; cardiac cell; cell therapy; delivery ... See more keywords
Requirements for Proper Immunosuppressive Regimens to Limit Translational Failure of Cardiac Cell Therapy in Preclinical Large Animal Models
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-020-10035-2
Abstract: Various cell-based therapies are currently investigated in an attempt to tackle the high morbidity and mortality associated with heart failure. The need for these therapies to move towards the clinic is pressing. Therefore, preclinical large… read more here.
Keywords: cardiac cell; large animal; preclinical large; immunosuppressive regimens ... See more keywords
Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.07.001
Abstract: Myocardial ischemia induces a multifaceted remodeling process in the heart. Novel therapeutic entry points to counteract maladaptive signalling include the modulation of non-coding RNA molecules such as long non-coding RNA (lncRNA). We here questioned if… read more here.
Keywords: cardiac cell; lncrna h19; cardiac functions; ischemia ... See more keywords
A phoenix rises from the ashes of cardiac cell therapy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-021-00625-1
Abstract: The field of cardiac cell therapy is under siege. Legacies of excessive hype, scientific misconduct and dead ends have fuelled the prevailing scepticism. However, promising clinical data, along with more trenchant mechanistic understanding, together provide… read more here.
Keywords: rises ashes; cardiac cell; cell therapy; cell ... See more keywords
Cardiac cell-derived exosomes: changing face of regenerative biology.
Sign Up to like & getrecommendations! Published in 2017 at "European heart journal"
DOI: 10.1093/eurheartj/ehw324
Abstract: This editorial refers to ‘Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction’, by R. Gallet et al ., doi:10.1093/eurheartj/ehw240 … The difference between… read more here.
Keywords: cardiac cell; cardiac tissue; cell; biology ... See more keywords
H2S Protects against Cardiac Cell Hypertrophy through Regulation of Selenoproteins
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/6494306
Abstract: Cardiac hypertrophy is defined as the enlargement of the cardiac myocytes, leading to improper nourishment and oxygen supply due to the increased functional demand. This increased stress on the cardiac system commonly leads to myocardial… read more here.
Keywords: cardiac cell; hypertrophy; cell; h2s protects ... See more keywords
Cardiac Cell Therapy Evolving From Complex to Straightforward: Enabling Adoption and Affordability.
Sign Up to like & getrecommendations! Published in 2017 at "Circulation Research"
DOI: 10.1161/circresaha.117.311947
Abstract: Numerous trials have evaluated mesenchymal stem/stromal cells (MSCs) derived from bone marrow (BM-MSCs) for a wide range of indications, including diseases of the cardiovascular system, as recently reviewed.1,2 Earlier this year, a seminal study evaluated… read more here.
Keywords: cardiac cell; cell therapy; tissue; mscs ... See more keywords
Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.321398
Abstract: Background: NOTCH1 pathogenic variants are implicated in multiple types of congenital heart defects including hypoplastic left heart syndrome, where the left ventricle is underdeveloped. It is unknown how NOTCH1 regulates human cardiac cell lineage determination… read more here.
Keywords: cell; notch1 knockout; heart; cardiac cell ... See more keywords
The Influence of the Timing of Cyclic Load Application on Cardiac Cell Contraction
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00917
Abstract: Cardiac cells are subjected to mechanical load during each heart-beat. Normal heart load is essential for physiological development and cardiac function. At the same time, excessive load can induce pathologies such as cardiac hypertrophy. While… read more here.
Keywords: cardiac cell; load; load application; response ... See more keywords
A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device
Sign Up to like & getrecommendations! Published in 2018 at "Bioengineering"
DOI: 10.3390/bioengineering5020036
Abstract: Three-dimensional (3D) models with cells arranged in clusters or spheroids have emerged as valuable tools to improve physiological relevance in drug screening. One of the challenges with cells cultured in 3D, especially for high-throughput applications,… read more here.
Keywords: spheroid chip; cardiac cell; cell outgrowth; drug ... See more keywords