Role of protein kinase C in metabolic regulation of the cardiac Na+ channel.
Sign Up to like & getrecommendations! Published in 2017 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2016.12.026
Abstract: BACKGROUND The reduced form of nicotinamide adenine dinucleotide (NADH) increases in cardiomyopathy, activates protein kinase C (PKC), up-regulates mitochondrial reactive oxygen species (mitoROS), and down-regulates the cardiac Na+ channel (NaV1.5). OBJECTIVE The purpose of this… read more here.
Keywords: cardiac channel; channel; single channel; protein kinase ... See more keywords
Local Anesthetic Like Inhibition of the Cardiac Na+ Channel Nav1.5 by Chloroquine and Hydroxychloroquine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Experimental Pharmacology"
DOI: 10.2147/jep.s375349
Abstract: Introduction Chloroquine (CQ) and its derivate hydroxychloroquine (HCQ) are successfully deployed for different diseases beyond the prophylaxis and treatment of malaria. Both substances exhibit antiviral properties and have been proposed for prophylaxis and treatment of… read more here.
Keywords: cardiac channel; inhibition; anesthetic like; local anesthetic ... See more keywords