Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.09.021
Abstract: Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) resemble fetal cardiomyocytes and electrical stimulation (ES) has been explored to mature the differentiated cells. Here, we hypothesize that ES applied at the beginning of the differentiation… read more here.
Keywords: cardiac conduction; conduction like; electrical stimulation; differentiation ... See more keywords
Heparan sulfate storage in the cardiac conduction system triggers atrioventricular block
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Development"
DOI: 10.1016/j.braindev.2016.12.008
Abstract: OBJECTIVE To elucidate the novel biological functions of heparan sulfate (HS) by clinic-pathologically studying a patient with paroxysmal atrioventricular (AV) block. PATIENT A long-surviving male patient with Sanfilippo syndrome type A presented with paroxysmal AV… read more here.
Keywords: storage; cardiac conduction; block; atrioventricular block ... See more keywords
Preprodynorphin gene mutation causes progressive cardiac conduction disease: A whole‐exome analysis of a pedigree
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.12.062
Abstract: Aims: Progressive cardiac conduction disease (PCCD) is a rare heart disease that usually shows familial inheritance. Potential genetic risk factors for PCCD have been mostly limited to genes that encode ion channels, cardiac transcription factors,… read more here.
Keywords: cardiac conduction; progressive cardiac; conduction disease; disease ... See more keywords
The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2018.08.003
Abstract: Cardiovascular disease remains the single largest cause of natural death in the United States, with a significant cause of mortality associated with cardiac arrhythmias. Presently, options for treating and preventing myocardial electrical dysfunction, including sudden… read more here.
Keywords: gap; cardiac conduction; anti arrhythmic; novel anti ... See more keywords
A radiotherapy contouring atlas for cardiac conduction node delineation.
Sign Up to like & getrecommendations! Published in 2021 at "Practical radiation oncology"
DOI: 10.1016/j.prro.2021.02.002
Abstract: INTRODUCTION The heart is a complex organ at risk. Radiotherapy cardiac delineation atlases do not currently include conduction system substructures, which exposure may clinically translate into arrhythmia and conduction disorders. We present a method for… read more here.
Keywords: radiotherapy contouring; cardiac conduction; delineation; node ... See more keywords
Generation of two iPSC lines (FAMRCi004-A and FAMRCi004-B) from patient with familial progressive cardiac conduction disorder carrying genetic variant DSP p.His1684Arg.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101720
Abstract: Human iPSC cell lines (FAMRCi004-A and FAMRCi004-B) were generated from patient with progressive cardiac conduction disease and sick sinus syndrome carrying DSP p.His1684Arg genetic variant. Patient-specific adipose tissue-derived mesenchymal multipotent stromal cells were reprogrammed using… read more here.
Keywords: cardiac conduction; progressive cardiac; lines famrci004; famrci004 famrci004 ... See more keywords
NOONAN SYNDROME AND THE CARDIAC CONDUCTION SYSTEM
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)32941-9
Abstract: Noonan syndrome (NS) is an autosomal dominant congenital disorder with various cardiovascular manifestations; however, conduction abnormalities are extremely rare. A 21-year-old Caucasian male with past medical history notable for Noonan syndrome presented to the emergency… read more here.
Keywords: noonan syndrome; syndrome cardiac; conduction; cardiology ... See more keywords
DeepMiceTL: a deep transfer learning based prediction of mice cardiac conduction diseases using early electrocardiograms.
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad109
Abstract: Cardiac conduction disease is a major cause of morbidity and mortality worldwide. There is considerable clinical significance and an emerging need of early detection of these diseases for preventive treatment success before more severe arrhythmias… read more here.
Keywords: conduction; transfer learning; deep transfer; cardiac conduction ... See more keywords
Lifestyle habits associated with cardiac conduction disease.
Sign Up to like & getrecommendations! Published in 2023 at "European heart journal"
DOI: 10.1093/eurheartj/ehac799
Abstract: AIMS Cardiac conduction disease can lead to syncope, heart failure, and death. The only available therapy is pacemaker implantation, with no established prevention strategies. Research to identify modifiable risk factors has been scant. METHODS AND… read more here.
Keywords: conduction disease; disease; lifestyle habits; block ... See more keywords
Microtubule cytoskeleton regulates connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene.
Sign Up to like & getrecommendations! Published in 2018 at "Human molecular genetics"
DOI: 10.1093/hmg/ddy227
Abstract: Mutations in the lamin A/C gene (LMNA) cause an autosomal dominant inherited form of dilated cardiomyopathy associated with cardiac conduction disease (hereafter referred to as LMNA cardiomyopathy). Compared with other forms of dilated cardiomyopathy, mutations… read more here.
Keywords: cardiomyopathy; cardiac conduction; microtubule cytoskeleton; lmna cardiomyopathy ... See more keywords
Pearson marrow‐pancreas syndrome with cardiac conduction abnormality necessitating prophylactic pacemaker implantation
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Noninvasive Electrocardiology"
DOI: 10.1111/anec.12681
Abstract: Pearson marrow‐pancreas syndrome (PS), an exceedingly rare mitochondrial disorder, involves multiple systems including hematologic system and pancreas. Other mitochondrial disorders have been associated with progressive infrahisian block but this has not yet been described as… read more here.
Keywords: marrow pancreas; pancreas syndrome; cardiac conduction; pearson marrow ... See more keywords