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Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202402457
Abstract: Cardiovascular disease (CVD) remains the leading cause of death worldwide. Patients often fail to recognize the early signs of CVDs, which display irregularities in cardiac contractility and may ultimately lead to heart failure. Therefore, continuously… read more here.
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Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13126
Abstract: Increasing attention is being given to patients with heart failure and ‘mid‐range’ left ventricular ejection fraction (LVEF, ≥40% and read more here.
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Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1349
Abstract: Heart failure (HF) is responsible for substantial morbidity and mortality and is increasing in prevalence. Although there has been remarkable progress in the treatment of HF with reduced ejection fraction (HFrEF), morbidity and mortality are… read more here.
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Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2619
Abstract: This pilot study aimed to assess the potential benefits of cardiac contractility modulation (CCM) in patients with heart failure with preserved ejection fraction (HFpEF). read more here.
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Published in 2020 at "Current Cardiology Reports"
DOI: 10.1007/s11886-020-01330-0
Abstract: Purpose of Review This review highlights the mechanisms of action of cardiac contractility modulation (CCM) and the clinical data which supports its use for the appropriate patient population. Recent Findings CCM has beneficial effects on… read more here.
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Published in 2017 at "HeartRhythm Case Reports"
DOI: 10.1016/j.hrcr.2017.02.004
Abstract: Key Teaching Points • Heart failure is a common health care problem. • Patients with heart failure and narrow QRS complexes who are refractory to medical therapy represent a management challenge, as they are not… read more here.
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Published in 2024 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvae088.017
Abstract: Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Doctoral fellowship Phosphoinositide 3-kinase C2α (PI3KC2α) is a ubiquitously expressed class II PI3K isoform, which has been previously shown to be involved… read more here.
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Published in 2021 at "Current opinion in cardiology"
DOI: 10.1097/hco.0000000000000929
Abstract: PURPOSE OF REVIEW Heart failure often progresses despite optimal medical and device therapies, and advanced mechanical circulatory support has limited availability and substantial associated morbidity. Cardiac contractility modulation (CCM) provides nonexcitatory stimulation to ventricular myocardium… read more here.
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Published in 2021 at "Journal of cardiovascular electrophysiology"
DOI: 10.1111/jce.15198
Abstract: Combined implantation of Cardiac Contractility Modulation (CCM) with subcutaneous ICD (S-ICD) appears a suitable option to reduce the amount of intracardiac leads and complications for patients. Here we report on a patient with ischemic cardiomyopathy… read more here.
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Published in 2024 at "Journal of Cardiovascular Electrophysiology"
DOI: 10.1111/jce.16222
Abstract: Cardiac contractility modulation (CCM) is a medical device‐based therapy delivering non‐excitatory electrical stimulations to the heart to enhance cardiac function in heart failure (HF) patients. The lack of human in vitro tools to assess CCM… read more here.
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Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.381
Abstract: Cardiac contractility is regulated by the intracellular Ca 2+ concentration fluxes which are actively regulated by multiple channels and transporters. Ca 2+ uptake into the mitochondrial matrix is precisely controlled by the highly Ca 2+… read more here.