Clinical effects of cardiac contractility modulation in heart failure with mildly reduced systolic function
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13126
Abstract: Increasing attention is being given to patients with heart failure and ‘mid‐range’ left ventricular ejection fraction (LVEF, ≥40% and read more here.
Keywords: heart; effects cardiac; contractility modulation; heart failure ... See more keywords
Cardiac contractility modulation: mechanisms of action in heart failure with reduced ejection fraction and beyond
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1349
Abstract: Heart failure (HF) is responsible for substantial morbidity and mortality and is increasing in prevalence. Although there has been remarkable progress in the treatment of HF with reduced ejection fraction (HFrEF), morbidity and mortality are… read more here.
Keywords: ejection fraction; heart; heart failure; reduced ejection ... See more keywords
Cardiac contractility modulation therapy improves health status in patients with heart failure with preserved ejection fraction: a pilot study (CCM‐HFpEF)
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2619
Abstract: This pilot study aimed to assess the potential benefits of cardiac contractility modulation (CCM) in patients with heart failure with preserved ejection fraction (HFpEF). read more here.
Keywords: heart failure; cardiac contractility; heart; contractility modulation ... See more keywords
Cardiac Contractility Monitoring: an Important Therapy in the Treatment of Advanced Heart Failure
Sign Up to like & getrecommendations! Published in 2020 at "Current Cardiology Reports"
DOI: 10.1007/s11886-020-01330-0
Abstract: Purpose of Review This review highlights the mechanisms of action of cardiac contractility modulation (CCM) and the clinical data which supports its use for the appropriate patient population. Recent Findings CCM has beneficial effects on… read more here.
Keywords: advanced heart; heart; heart failure; therapy ... See more keywords
Cardiac contractility modulation therapy: Are there superresponders?
Sign Up to like & getrecommendations! Published in 2017 at "HeartRhythm Case Reports"
DOI: 10.1016/j.hrcr.2017.02.004
Abstract: Key Teaching Points • Heart failure is a common health care problem. • Patients with heart failure and narrow QRS complexes who are refractory to medical therapy represent a management challenge, as they are not… read more here.
Keywords: heart; contractility modulation; heart failure; therapy ... See more keywords
The emerging role of cardiac contractility modulation in heart failure treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in cardiology"
DOI: 10.1097/hco.0000000000000929
Abstract: PURPOSE OF REVIEW Heart failure often progresses despite optimal medical and device therapies, and advanced mechanical circulatory support has limited availability and substantial associated morbidity. Cardiac contractility modulation (CCM) provides nonexcitatory stimulation to ventricular myocardium… read more here.
Keywords: heart; role; cardiac contractility; heart failure ... See more keywords
Device interaction between Cardiac-Contractility-Modulation (CCM) und subcutaneus Defibrillator (S-ICD).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiovascular electrophysiology"
DOI: 10.1111/jce.15198
Abstract: Combined implantation of Cardiac Contractility Modulation (CCM) with subcutaneous ICD (S-ICD) appears a suitable option to reduce the amount of intracardiac leads and complications for patients. Here we report on a patient with ischemic cardiomyopathy… read more here.
Keywords: modulation ccm; cardiac contractility; icd; ccm ... See more keywords
Abstract 381: Mcur1 is a Potential Target to Modulate Cardiac Contractility and Alleviate Cardiac Function During Heart Failure
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.381
Abstract: Cardiac contractility is regulated by the intracellular Ca 2+ concentration fluxes which are actively regulated by multiple channels and transporters. Ca 2+ uptake into the mitochondrial matrix is precisely controlled by the highly Ca 2+… read more here.
Keywords: mcu; cardiac function; heart failure; contractility ... See more keywords
Use of Cardiac Contractility Modulation as Bridge to Transplant in an Obese Patient With Advanced Heart Failure: A Case Report
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.833143
Abstract: Cardiac contractility modulation (CCM) is a novel device-based therapy in patients with heart failure with reduced ejection fraction (HFrEF). In randomized clinical trials and real-life studies, CCM has been shown to improve exercise tolerance and… read more here.
Keywords: cardiac contractility; patient; heart; heart failure ... See more keywords
Regulation of Cardiac Contractility by the Alpha 2 Subunit of the Na+/K+-ATPase
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.827334
Abstract: Cytosolic Na + concentrations regulate cardiac excitation-contraction coupling and contractility. Inhibition of the Na+/K+-ATPase (NKA) activity increases cardiac contractility by increasing cytosolic Ca2+ levels, as increased cytosolic Na+ levels are coupled to less Ca2+ extrusion… read more here.
Keywords: cardiac contractility; nka; contractility; subunit ... See more keywords
Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish
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DOI: 10.3390/biom8040153
Abstract: Patients with inherited dilated cardiomyopathy (DCM) often suffer from severe heart failure based on impaired cardiac contractility leading to increased morbidity and mortality. Integrin-linked kinase (ILK) as a part of the cardiac mechanical stretch sensor… read more here.
Keywords: deficient zebrafish; pkb phosphorylation; ilk; ilk deficient ... See more keywords