Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Research"
DOI: 10.1080/10715762.2018.1453137
Abstract: Abstract The multipurpose organelle mitochondria play an essential role(s) in controlling cardiac muscle contraction. Mitochondria, not only function as the powerhouses and the energy source of myocytes but also modulate intracellular Ca2+ homeostasis, the production… read more here.
Keywords: mitochondria regulate; cardiac contraction; atp dependent; regulate cardiac ... See more keywords
From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery
Sign Up to like & getrecommendations! Published in 2017 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfw227
Abstract: Cardiotoxicity is a common cause of attrition in preclinical and clinical drug development. Current in vitro approaches have two main limitations, they either are limited to low throughput methods not amendable to drug discovery or… read more here.
Keywords: cardiac microtissues; throughput; cardiac contraction; drug ... See more keywords