A guide in lentiviral vector production for hard-to-transfect cells, using cardiac-derived c-kit expressing cells as a model system
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98657-7
Abstract: Gene therapy revolves around modifying genetic makeup by inserting foreign nucleic acids into targeted cells via gene delivery methods to treat a particular disease. While the genes targeted play a key role in gene therapy,… read more here.
Keywords: production; system; gene therapy; cardiac derived ... See more keywords
Minimizing the risk of allo-sensitization to optimize the benefit of allogeneic cardiac-derived stem/progenitor cells
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DOI: 10.1038/srep41125
Abstract: Allogeneic human cardiac-derived stem/progenitor cells (hCPC) are currently under clinical investigation for cardiac repair. While cellular immune response against allogeneic hCPC could be part of their beneficial-paracrine effects, their humoral immune response remains largely unexplored.… read more here.
Keywords: dsa hla; risk; cardiac derived; derived stem ... See more keywords
Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure
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DOI: 10.1161/circresaha.122.320916
Abstract: Background: Chronic heart failure (CHF) is associated with redox imbalance. Downregulation of Nrf2 (nuclear factor [erythroid-derived 2]-like 2) plays important roles in disrupting myocardial redox homeostasis and mediating sympathetic nerve activity in the setting of… read more here.
Keywords: heart failure; excitation; cardiac derived; evs ... See more keywords