Comprehensive Overview of Non-coding RNAs in Cardiac Development.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1671-9_11
Abstract: Cardiac development in the human embryo is characterized by the interactions of several transcription and growth factors leading the heart from a primordial linear tube into a synchronous contractile four-chamber organ. Studies on cardiogenesis showed… read more here.
Keywords: coding rnas; non coding; comprehensive overview; overview non ... See more keywords
Using Zebrafish to Analyze the Genetic and Environmental Etiologies of Congenital Heart Defects.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-2389-2_8
Abstract: Congenital heart defects (CHDs) are among the most common human birth defects. However, the etiology of a large proportion of CHDs remains undefined. Studies identifying the molecular and cellular mechanisms that underlie cardiac development have… read more here.
Keywords: using zebrafish; genetic environmental; congenital heart; heart defects ... See more keywords
Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108404
Abstract: Stressful experiences early in life can increase the risk of cardiovascular diseases. However, it remains largely unknown how stress influences susceptibility to the disease onset. Here, we show that exposure to brain-processed stress disrupts myocardial… read more here.
Keywords: glucocorticoid; stress; early life; cardiac development ... See more keywords
Acute toxicity of the insecticide EPN upon zebrafish (Danio rerio) embryos and its related adverse effects: Verification of abnormal cardiac development and seizure-like events.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112544
Abstract: Toxicological studies of O-ethyl-O-(4-nitrophenyl) phenylphosphonothioate (EPN) to aquatic vertebrates have been reported, but no reports on toxic mechanism was reported. As zebrafish (Danio rerio) embryos were exposed to EPN, no changes in their survival and… read more here.
Keywords: rerio embryos; embryos; zebrafish danio; development ... See more keywords
Effects of uteroplacental insufficiency on cardiac development in growth-restricted newborn rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174422000575
Abstract: Abstract Fetal growth restriction (FGR) is associated with reduced cardiac function in neonates. Uteroplacental insufficiency (UPI) is the most common cause of FGR. The mechanisms underlying these alterations remain unknown. We hypothesized that UPI would… read more here.
Keywords: growth; uteroplacental insufficiency; cardiac development; restricted newborn ... See more keywords
Transient cardiomyocyte fusion regulates cardiac development in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01555-8
Abstract: Cells can sacrifice their individuality by fusing, but the prevalence and significance of this process are poorly understood. To approach these questions, here we generate transgenic reporter lines in zebrafish to label and specifically ablate… read more here.
Keywords: fusion; transient cardiomyocyte; cardiomyocyte fusion; cardiac development ... See more keywords
Epicardium in Heart Development.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a037192
Abstract: The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and regeneration and has been implicated in potential strategies for cardiac repair. The heterogenous cell population that… read more here.
Keywords: epicardium; heart development; biology; development ... See more keywords
Long Noncoding RNAs in Cardiac Development.
Sign Up to like & getrecommendations! Published in 2020 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a037374
Abstract: The exquisite transcriptional control of developmental gene programs is critical for hardwiring the complex expression patterns that govern cell-fate determination and differentiation during heart development. During the past several years, studies have illuminated our understanding… read more here.
Keywords: long noncoding; noncoding rnas; rnas cardiac; development ... See more keywords
A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005828
Abstract: Blood flow and mechanical forces in the ventricle are implicated in cardiac development and trabeculation. However, the mechanisms of mechanotransduction remain elusive. This is due in part to the challenges associated with accurately quantifying mechanical… read more here.
Keywords: sheet imaging; trabeculation; light sheet; development ... See more keywords
MicroRNA-29c affects zebrafish cardiac development via targeting Wnt4
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11584
Abstract: As a single cardiac malformation, ventricular septal defect (VSD) is the most common form of congenital heart disease. However, the precise molecular mechanisms underlying VSD are not completely understood. Numerous microRNAs (miRs/miRNAs) are associated with… read more here.
Keywords: heart; microrna 29c; targeting wnt4; mir 29c ... See more keywords