Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated-oxidative stress generation.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental toxicology"
DOI: 10.1002/tox.23485
Abstract: Due to an increasing number of abused drugs dumped into the wastewater, more and more drugs are detected in the water environment, which may affect the survival of aquatic organisms. Lenvatinib is a multi-targeted tyrosine… read more here.
Keywords: cardiac developmental; notch; stress; zebrafish embryos ... See more keywords
Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Evidence for its cardiac developmental toxicity.
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DOI: 10.1016/j.tox.2020.152422
Abstract: Ribavirin has been proven to be an antiviral treatment, whereas there are still risks of hemolysis and congenital malformation. Abnormal cardiac development contributes to the occurrence and development of many heart diseases. However, there is… read more here.
Keywords: phase; human induced; evidence; differentiation ... See more keywords
Arsenic trioxide blocked proliferation and cardiomyocyte differentiation of human induced pluripotent stem cells: Implication in cardiac developmental toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.03.008
Abstract: Arsenic trioxide (ATO) has been recommended as the first-line agent for the treatment of acute promyelocytic leukaemia (APL), due to its substantial anticancer effect. Numerous clinical reports have indicated that ATO is a developmental toxicant… read more here.
Keywords: arsenic trioxide; human induced; differentiation; cardiac developmental ... See more keywords