Heme oxygenase‐1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1711
Abstract: Cellular stress can influence efficiency of iPSCs generation and their differentiation. However, the role of intracellular cytoprotective factors in these processes is still not well known. Therefore, we investigated the effect of HO‐1 (Hmox1) or… read more here.
Keywords: spontaneous cardiac; ipscs; generation; differentiation ... See more keywords
The status of MAPK cascades contributes to the induction and activation of Gata4 and Nkx2.5 during the stepwise process of cardiac differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.11.019
Abstract: Cardiac differentiation in vitro is a complex, stepwise process that is rigidly governed by a subset of transcription factors and signaling cascades. In this study, we investigated the cooperation of cardiac-specific transcription factors Gata4 and… read more here.
Keywords: mapk; differentiation; activation; stage ... See more keywords
Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation: Functional assessment using in vitro radionuclide uptake assay.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.06.089
Abstract: BACKGROUND Recent developments in cellular reprogramming technology enable the production of virtually unlimited numbers of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). Although hiPSC-CM share various characteristic hallmarks with endogenous cardiomyocytes, it remains a question… read more here.
Keywords: shift; human induced; differentiation; pluripotent stem ... See more keywords
A novel cardiac differentiation method of a large number and uniformly-sized spheroids using microfabricated culture vessels
Sign Up to like & getrecommendations! Published in 2020 at "Regenerative Therapy"
DOI: 10.1016/j.reth.2020.04.008
Abstract: Cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs) have great potential for regenerative medicine and drug discovery. In this study, we developed a novel protocol to more reproducibly and efficiently induce cardiomyocytes. A large… read more here.
Keywords: spheroids using; uniformly sized; using microfabricated; sized spheroids ... See more keywords
Arsenic trioxide blocked proliferation and cardiomyocyte differentiation of human induced pluripotent stem cells: Implication in cardiac developmental toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.03.008
Abstract: Arsenic trioxide (ATO) has been recommended as the first-line agent for the treatment of acute promyelocytic leukaemia (APL), due to its substantial anticancer effect. Numerous clinical reports have indicated that ATO is a developmental toxicant… read more here.
Keywords: arsenic trioxide; human induced; differentiation; cardiac developmental ... See more keywords
Uric acid: a potent molecular contributor to pluripotent stem cell cardiac differentiation via mesoderm specification
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-018-0157-9
Abstract: Congenital heart disease (CHD) is the most common cause of congenital anomaly and a leading cause of morbidity and mortality worldwide. Generation of cardiomyoctyes derived from pluripotent stem cells (PSCs) has opened new avenues for… read more here.
Keywords: uric acid; specification; differentiation; pluripotent stem ... See more keywords
Genetic and Epigenetic Profiling Reveals EZH2-mediated Down Regulation of OCT-4 Involves NR2F2 during Cardiac Differentiation of Human Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13442-9
Abstract: Human embryonic (hES) stem cells are widely used as an in vitro model to understand global genetic and epigenetic changes that occur during early embryonic development. In-house derived hES cells (KIND1) were subjected to directed… read more here.
Keywords: profiling; differentiation; genetic epigenetic; stem cells ... See more keywords
CXCL4/PF4 is a predictive biomarker of cardiac differentiation potential of human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40915-w
Abstract: Selection of human induced pluripotent stem cell (hiPSC) lines with high cardiac differentiation potential is important for regenerative therapy and drug screening. We aimed to identify biomarkers for predicting cardiac differentiation potential of hiPSC lines… read more here.
Keywords: biomarker; human induced; differentiation potential; hipsc lines ... See more keywords
Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxab017
Abstract: Ten-eleven Translocation (TET) dioxygenases mediated DNA methylation oxidation plays an important role in regulating the embryonic stem cells (ESCs) differentiation. Herein, we utilized a CRISPR/Cas9 based genome editing method to generate single, double, and triple… read more here.
Keywords: ten eleven; cardiac differentiation; differentiation; eleven translocation ... See more keywords
Pioglitazone Mediates Cardiac Progenitor Formation through Increasing ROS Levels
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1480345
Abstract: In order to achieve a sufficient population of cardiac-committed progenitor cells, it is crucial to know the mechanisms of cardiac progenitor formation. Previous studies suggested ROS effect on cardiac commitment events to play a key… read more here.
Keywords: progenitor; progenitor formation; cardiac differentiation; ros ... See more keywords
Cardiac Differentiation Promotes Focal Adhesions Assembly through Vinculin Recruitment
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032444
Abstract: Cells of the cardiovascular system are physiologically exposed to a variety of mechanical forces fundamental for both cardiac development and functions. In this context, forces generated by actomyosin networks and those transmitted through focal adhesion… read more here.
Keywords: adhesions assembly; cardiac differentiation; differentiation; differentiation promotes ... See more keywords