α2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23304-7
Abstract: Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α2A-adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced… read more here.
Keywords: cardiac endothelial; norepinephrine concentration; blockade attenuates; cardiac norepinephrine ... See more keywords
SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Research"
DOI: 10.1186/s12931-019-1079-x
Abstract: BackgroundRight ventricular (RV) angiogenesis has been associated with adaptive myocardial remodeling in pulmonary hypertension (PH), though molecular regulators are poorly defined. Endothelial cell VEGFR-2 is considered a “master regulator” of angiogenesis in other models, and… read more here.
Keywords: cardiac endothelial; murine; angiogenesis; endothelial cell ... See more keywords
Ketone body oxidation increases cardiac endothelial cell proliferation.
Sign Up to like & getrecommendations! Published in 2022 at "EMBO molecular medicine"
DOI: 10.15252/emmm.202114753
Abstract: Blood vessel formation is dependent on metabolic adaption in endothelial cells. Glucose and fatty acids are essential substrates for ATP and biomass production; however, the metabolism of other substrates remains poorly understood. Ketone bodies are… read more here.
Keywords: cell proliferation; ketone body; cardiac endothelial; ketone ... See more keywords