Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27165
Abstract: Bioactive lipid mediators derived from n‐3 and n‐6 fatty acids are known to modulate leukocytes. Metabolic transformation of essential fatty acids to endogenous bioactive molecules plays a major role in human health. Here we tested… read more here.
Keywords: cardiac fibroblast; peritoneal macrophages; rvd1; fibroblast phenotypes ... See more keywords
DNA methyltransferase-1 inactivation of androgen receptor axis triggers homocysteine induced cardiac fibroblast autophagy in diabetic cardiac fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108521
Abstract: Diabetic cardiac fibrosis is one of the main pathological manifestations of diabetic cardiomyopathy (DCM). Cardiac fibroblast autophagy plays critical roles in diabetic cardiac fibrosis, however, the underlying mechanism of cardiac fibroblast autophagy and diabetic cardiac… read more here.
Keywords: diabetic cardiac; fibroblast; cardiac fibroblast; cardiac fibrosis ... See more keywords
Long non-coding RNA Linc00092 inhibits cardiac fibroblast activation by altering glycolysis in an ERK-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109708
Abstract: AIMS Cardiac fibroblast (CF) activation is the key event for cardiac fibrosis. The role of glycolysis and the glycolysis-related lncRNAs in CF activation are unknown. Thus, we aimed to investigate the role of glycolysis in… read more here.
Keywords: glycolysis; cardiac fibroblast; hcf activation; linc00092 ... See more keywords
Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174805
Abstract: Myocardial fibrosis is a concomitant bioprocess associated with many cardiovascular diseases (CVDs). Daidzein is an isoflavone that has been used for the treatment of CVDs. This study aimed to reveal its role in myocardial fibrosis.… read more here.
Keywords: tgf; induced cardiac; cardiac fibroblast; signaling pathway ... See more keywords
GW28-e0733 Cardiac Fibroblast SWELL1 Regulates Ventricular Remodeling and Dysfunction Following Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.089
Abstract: Myocardial infarction (MI)-induced cardiac remodeling includes chamber dilatation, contractile dysfunction, and fibrosis. Of these, fibrosis is the least understood. After MI, activated cardiac fibroblasts deposit extracellular matrix, leading to pathological myocardial fibrosis. Current therapies read more here.
Keywords: e0733 cardiac; cardiac fibroblast; dysfunction; myocardial infarction ... See more keywords
Knock‐out of MicroRNA 145 impairs cardiac fibroblast function and wound healing post‐myocardial infarction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15597
Abstract: Prevention of infarct scar thinning and dilatation and stimulation of scar contracture can prevent progressive heart failure. Since microRNA 145 (miR‐145) plays an important role in cardiac fibroblast response to wound healing and cardiac repair… read more here.
Keywords: function; cardiac fibroblast; microrna 145; mir 145 ... See more keywords
Abstract 522: IL-10 Knockout Bone Marrow Fibroblast Progenitor Cells-derived Exosomes Activate Cardiac Fibroblast and Exaggerate Pressure Overload-induced Fibrosis in Mice Heart
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.522
Abstract: Background: Inflammatory mediators play important role in cardiac remodeling. In heart, fibrosis is mainly mediated by activated fibroblasts (myofibroblasts), however, origin of myofibroblasts in diseased heart remains unclear. Recently, we have shown that bone marrow… read more here.
Keywords: heart; fibrosis; fibroblast; cardiac fibroblast ... See more keywords
Abstract 415: Asporin Contributes to Reactive Interstitial Cardiac Fibrosis by Regulating Cardiac Fibroblast Activation
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.415
Abstract: Cardiac fibrosis critically contributes to heart failure progression. Depending on the pathological insult, cardiac fibrosis either replaces necrotic cardiomyocytes or is reactive to cardiac fibroblast (CF) activation. The extracellular matrix (ECM) consists of various proteins… read more here.
Keywords: fibrosis; cardiac fibroblast; cardiac fibrosis; reactive interstitial ... See more keywords
Abstract 421: Norepinephrine Catabolism Drives Cardiac Fibroblast Activation via Monoamine Oxidase Activity and Rage/β-adrenergic Signaling
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DOI: 10.1161/res.127.suppl_1.421
Abstract: The mitochondrial enzyme monoamine oxidase A (MAO-A) plays an increasingly appreciated role in cardiac remodeling induced by diabetes and ischemic injury. Oxidative deamination of norepinephrine (NE) by MAO-A generates 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and H 2 O… read more here.
Keywords: catabolism; oxidase; cardiac fibroblast; mao ... See more keywords
Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.664626
Abstract: Cardiac remodeling consisted of ventricular hypertrophy and interstitial fibrosis is the pathological process of many heart diseases. Fibroblasts as one of the major cells in the myocardium regulate the balance of the generation and degeneration… read more here.
Keywords: induced cardiac; cardiac fibroblast; cardiac remodeling; fibroblast specific ... See more keywords
Glycolysis Inhibition Alleviates Cardiac Fibrosis After Myocardial Infarction by Suppressing Cardiac Fibroblast Activation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.701745
Abstract: Objective: To explore the role of glycolysis in cardiac fibroblast (CF) activation and cardiac fibrosis after myocardial infarction (MI). Method: In vivo: 2-Deoxy-D-glucose (2-DG), a glycolysis inhibitor, was injected into the abdominal cavity of the… read more here.
Keywords: fibrosis; glycolysis; cardiac fibroblast; cardiac fibrosis ... See more keywords