Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27117
Abstract: Cardiac fibrosis is a pathological remodeling response to myocardial infarction (MI) and impairs cardiac contractility. Long noncoding RNA (lncRNA) metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) is increased in patients with MI. However, the functions of… read more here.
Keywords: long noncoding; fibrosis; noncoding rna; cardiac fibrosis ... See more keywords
Generation of Quiescent Cardiac Fibroblasts Derived from Human Induced Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/7651_2020_300
Abstract: Myocardial fibrosis is a hallmark of cardiac remodeling, which can progressively lead to heart failure, a leading cause of death worldwide. The effector cells of fibrosis in the heart are cardiac fibroblasts (CFs). There is… read more here.
Keywords: quiescent; human induced; pluripotent stem; cardiac fibroblasts ... See more keywords
Properties and Immune Function of Cardiac Fibroblasts.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-57613-8_3
Abstract: This chapter will discuss the role of cardiac fibroblasts as a target of various immunological inputs as well as an immunomodulatory hub of the heart through interaction with immune cell types and chemokine or cytokine… read more here.
Keywords: properties immune; biology; cardiac fibroblasts; function cardiac ... See more keywords
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1529-1
Abstract: Wnt signaling is dysregulated in heart failure (HF) and may promote cardiac hypertrophy, fibrosis, and inflammation. Blocking the Wnt ligand Wnt5a prevents HF in animal models. However, the role of Wnt5a in human HF and… read more here.
Keywords: wnt5a elevated; cardiac fibroblasts; heart failure; wnt5a ... See more keywords
Ischemia does not provoke the full immune training repertoire in human cardiac fibroblasts
Sign Up to like & getrecommendations! Published in 2024 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-024-03107-6
Abstract: Trained immunity of monocytes, endothelial, and smooth muscle cells augments the cytokine response to secondary stimuli. Immune training is characterized by stabilization of hypoxia-inducible factor (HIF)-1α, mTOR activation, and aerobic glycolysis. Cardiac fibroblast (CF)-myofibroblast transition… read more here.
Keywords: ldh; cardiac fibroblasts; mtor; immune training ... See more keywords
Development and characterization of anti-fibrotic natural compound similars with improved effectivity
Sign Up to like & getrecommendations! Published in 2022 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-022-00919-6
Abstract: Cardiac fibroblasts constitute the major cell type of the murine and human heart. Once activated, they contribute to an excessive deposition of extracellular matrix (ECM) leading to cardiac fibrosis and subsequently organ dysfunction. With the… read more here.
Keywords: anti fibrotic; fibrotic properties; cardiac fibroblasts; compound ... See more keywords
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2956-6
Abstract: The aim of this study is to investigate the effect of evodiamine on fibroblast activation in cardiac fibroblasts and endothelial to mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs). Neonatal rat cardiac fibroblasts… read more here.
Keywords: endothelial mesenchymal; huvecs; cardiac fibroblasts; activation ... See more keywords
Role of Cardiac Fibroblasts in Cardiac Injury and Repair
Sign Up to like & getrecommendations! Published in 2022 at "Current Cardiology Reports"
DOI: 10.1007/s11886-022-01647-y
Abstract: Purpose of Review The pathological remodeling of cardiac tissue after injury or disease leads to scar formation. Our knowledge of the role of nonmyocytes, especially fibroblasts, in cardiac injury and repair continues to increase with… read more here.
Keywords: injury; repair; injury repair; cardiac injury ... See more keywords
Cyclosporin A induces autophagy in cardiac fibroblasts through the NRP-2/WDFY-1 axis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.02.017
Abstract: Cyclosporin A (CsA) is an effective immunosuppressive agent, but its myocardial toxicity limits its widespread and long-term clinical application. In this study, CsA treatment led to damages in myocardial fiber structure, an increase in myocardial… read more here.
Keywords: fibrosis; cyclosporin; cardiac fibroblasts; nrp wdfy ... See more keywords
ERK1/2 mediates the lipopolysaccharide-induced upregulation of FGF-2, uPA, MMP-2, MMP-9 and cellular migration in cardiac fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.04.010
Abstract: Myocardial fibrosis is a critical event during septic shock. Upregulation in the fibrosis signaling cascade proteins such as fibroblast growth factor (FGF), urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and activation of matrix metalloproteinases… read more here.
Keywords: induced upregulation; mmp; fgf upa; cardiac fibroblasts ... See more keywords
Oxytocin induces intracellular Ca2+ release in cardiac fibroblasts from neonatal rats.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.102099
Abstract: Pituitary neuropeptide oxytocin is increasingly recognised as a cardiovascular hormone, in addition to its many regulatory roles in other organ systems. Studies in atrial and ventricular myocytes from the neonatal and adult rats have identified… read more here.
Keywords: oxytocin induces; oxytocin; cardiac fibroblasts; intracellular ca2 ... See more keywords