Legumain In Situ Engineering Promotes Efferocytosis of CAR Macrophage to Treat Cardiac Fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202417831
Abstract: Uncontrolled and excessive cardiac fibrosis after myocardial infarction (MI) is a primary contributor to mortality by heart failure. Chimeric antigen receptor macrophage (CAR‐MΦ) therapy shows great promise in cardiac fibrosis, however, the overwhelming apoptotic cells… read more here.
Keywords: fibrosis; macrophage; car; cardiac fibrosis ... See more keywords
CAR‐T cell therapeutic avenue for fighting cardiac fibrosis: Roadblocks and perspectives
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3955
Abstract: Heart diseases remain the primary cause of human mortality in the world. Although conventional therapeutic opportunities fail to halt or recover cardiac fibrosis, the promising clinical results and therapeutic efficacy of engineered chimeric antigen receptor… read more here.
Keywords: car cell; car; cell; cardiac fibrosis ... See more keywords
The paired‐related homeobox protein 1 promotes cardiac fibrosis via the Twist1‐Prrx1‐tenascin‐C loop
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11944
Abstract: Cardiac fibrosis is a common pathology in the advanced stage of cardiovascular diseases, which leads to cardiac systolic and diastolic dysfunction. It is important to prevent cardiac fibrosis during myocardial injury. The transcription factor Prrx1… read more here.
Keywords: prrx1; cardiac fibrosis; paired related; twist1 prrx1 ... See more keywords
Crosstalk between the activated Slit2–Robo1 pathway and TGF‐β1 signalling promotes cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13095
Abstract: Previous reports indicated that the Slit2–Robo signalling pathway is involved in embryonic heart development and fibrosis in other solid organs, but its function in adult cardiac fibrosis has not been investigated. Here, we investigate the… read more here.
Keywords: fibrosis; cardiac fibrosis; activated slit2; slit2 robo1 ... See more keywords
Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid‐binding protein 5
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14318
Abstract: The activation of cardiac fibroblasts (CFs) leads to overproduction of collagens and subsequently cardiac fibrosis. However, the regulatory mechanism of CF function in the process of cardiac fibrosis remains unclear. This work investigated the function… read more here.
Keywords: binding protein; cardiac fibrosis; polypyrimidine tract; fibrosis ... See more keywords
Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27117
Abstract: Cardiac fibrosis is a pathological remodeling response to myocardial infarction (MI) and impairs cardiac contractility. Long noncoding RNA (lncRNA) metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) is increased in patients with MI. However, the functions of… read more here.
Keywords: long noncoding; fibrosis; noncoding rna; cardiac fibrosis ... See more keywords
Adult cardiomyocytes‐derived EVs for the treatment of cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12461
Abstract: Abstract Cardiac fibrosis is a common pathological feature of cardiovascular diseases that arises from the hyperactivation of fibroblasts and excessive extracellular matrix (ECM) deposition, leading to impaired cardiac function and potentially heart failure or arrhythmia.… read more here.
Keywords: derived evs; treatment cardiac; treatment; fibrosis ... See more keywords
Plantamajoside attenuates cardiac fibrosis via inhibiting AGEs activated‐RAGE/autophagy/EndMT pathway
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7663
Abstract: Advanced glycation end products (AGEs) have been identified to transduce fibrogenic signals via inducing the activation of their receptor (RAGE)‐mediated pathway. Recently, disrupting AGE‐RAGE interaction has become a promising therapeutic strategy for chronic heart failure… read more here.
Keywords: cardiac fibrosis; rage autophagy; rage; fibrosis ... See more keywords
Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D‐galactose induced aging in rats
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22671
Abstract: Cardiac fibrosis is a common pathophysiological process observed during chronic and stress‐induced acceleration of cardiac aging. Fibrosis is a necessary process during wound healing and tissue repair. However, its deposition in organs would proceed to… read more here.
Keywords: fibrosis; cardiac fibrosis; fibrosis associated; galactose induced ... See more keywords
Cardiac Fibrosis: The Beneficial Effects of Exercise in Cardiac Fibrosis.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-4307-9_14
Abstract: Numerous scientific findings have concluded that individuals who are active tend to develop less cardiovascular disease than those who enjoy more sedentary lifestyles. Animal models have further demonstrated that the beneficial effects of training on… read more here.
Keywords: heart; fibrosis; exercise cardiac; cardiac fibrosis ... See more keywords
Circular RNAs as potential theranostics in the cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Heart Failure Reviews"
DOI: 10.1007/s10741-019-09908-9
Abstract: Circular RNAs (circRNAs) are a type of single-stranded RNA molecules that normally do not encode proteins. circRNAs are involved in many physiological processes as well as the pathogenesis of diseases. Cardiac fibrosis is increasingly recognized… read more here.
Keywords: circular rnas; potential theranostics; fibrosis; theranostics cardiac ... See more keywords