The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Genetics and Metabolism Reports"
DOI: 10.1016/j.ymgmr.2017.07.011
Abstract: Cardiac glycosides are plant-derived molecules that have shown antiproliferative properties against cancer cells, though the mechanism of action is not completely understood. We show that one cardiac glycoside, convallatoxin, presents antiproliferative effects against colorectal cancer… read more here.
Keywords: colorectal cancer; glycoside convallatoxin; cancer cells; cancer ... See more keywords
The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00094
Abstract: A cardiac glycoside epoxide, (-)-cryptanoside A (1), was isolated from the stems of Cryptolepis dubia collected in Laos, for which the complete structure was confirmed by analysis of its spectroscopic and single-crystal X-ray diffraction data,… read more here.
Keywords: glycoside; cryptanoside; cardiac glycoside; cryptolepis dubia ... See more keywords
Fatal cardiac glycoside poisoning due to mistaking foxglove for comfrey
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Toxicology"
DOI: 10.1080/15563650.2017.1317350
Abstract: Abstract Context: Accidental ingestion of foxglove (Digitalis purpurea) can cause significant cardiac toxicity. We report a patient who ingested foxglove mistaking it for comfrey and developed refractory ventricular arrhythmias. The patient died despite treatment with… read more here.
Keywords: glycoside poisoning; comfrey; cardiac glycoside; fatal cardiac ... See more keywords
Cardiac arrhythmias, electrolyte abnormalities and serum cardiac glycoside concentrations in yellow oleander (Cascabela thevetia) poisoning – a prospective study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Toxicology"
DOI: 10.1080/15563650.2018.1499930
Abstract: Abstract Background: Consumption of yellow oleander (Cascabela thevetia) is a popular method of intentional self-harm in South India. Objectives: The objectives of this study were to identify the cardiac arrhythmias and electrolyte abnormalities in yellow… read more here.
Keywords: glycoside; arrhythmias; glycoside concentration; cardiac glycoside ... See more keywords
A novel source of the cardiac glycoside digoxin from the endophytic fungus Epicoccum nigrum: isolation, characterization, production enhancement by gamma irradiation mutagenesis and anticancer activity evaluation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.14510
Abstract: Different endophytic fungi were isolated and screened for their digoxin‐producing ability. Strain improvement and different culture conditions were studied for more effective production of digoxin. read more here.
Keywords: digoxin; production; novel source; glycoside digoxin ... See more keywords