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   Articles with "cardiac hypertrophy" as a keyword



Genome‐wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy

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recommendations! Published in 2021 at "FEBS Letters"

DOI: 10.1002/1873-3468.14168

Abstract: LIM‐domain proteins have been shown to be associated with heart development and diseases. Systematic studies of LIM family members at the genome‐wide level, which are crucial to further understand their functions in cardiac hypertrophy, are… read more here.

Keywords: genome wide; cardiac hypertrophy; analysis mouse; family ... See more keywords
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HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.

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recommendations! Published in 2023 at "Advanced science"

DOI: 10.1002/advs.202300585

Abstract: Inhibition of pathological cardiac hypertrophy is recognized as an important therapeutic strategy for heart failure, although effective targets are still lacking in clinical practice. Homeodomain interacting protein kinase 1 (HIPK1) is a conserved serine/threonine kinase… read more here.

Keywords: pathological cardiac; hypertrophy; hipk1; cardiac hypertrophy ... See more keywords

SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202305677

Abstract: Pathological cardiac hypertrophy is the leading cause of heart failure and has an extremely complicated pathogenesis. TEA domain transcription factor 1 (TEAD1) is recognized as an important transcription factor that plays a key regulatory role… read more here.

Keywords: cardiac hypertrophy; hypertrophy; pathological cardiac; sumoylation tead1 ... See more keywords

The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9‐Mediated Splicing of NFATc4

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202308769

Abstract: Cardiac hypertrophy is a key factor driving heart failure (HF), yet its pathogenesis remains incompletely elucidated. Mettl1‐catalyzed RNA N7‐methylguanosine (m7G) modification has been implicated in ischemic cardiac injury and fibrosis. This study aims to elucidate… read more here.

Keywords: cardiac hypertrophy; hypertrophy; m7g methyltransferase; srsf9 ... See more keywords

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202507365

Abstract: Heart failure (HF) as the terminal stage of various cardiac diseases, its underlying molecular mechanisms still remain elusive. Emerging evidence have implicated long noncoding RNAs (lncRNAs) play a multifaceted role in the progression of cardiac… read more here.

Keywords: cardiac hypertrophy; hypertrophy; foxo6os novel; heart failure ... See more keywords

Chrysophanol attenuated isoproterenol‐induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

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recommendations! Published in 2019 at "Cell Biology International"

DOI: 10.1002/cbin.11146

Abstract: Cardiac hypertrophy is a common pathological change found in various cardiovascular diseases. Although it has long been recognized as an important risk factor responsible for heart failure, there is still a lack of effective treatments… read more here.

Keywords: cardiac hypertrophy; transcription; induced cardiac; hypertrophy ... See more keywords

Up‐regulation of SNHG16 induced by CTCF accelerates cardiac hypertrophy by targeting miR‐182‐5p/IGF1 axis

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recommendations! Published in 2020 at "Cell Biology International"

DOI: 10.1002/cbin.11333

Abstract: Long non‐coding RNA (lncRNA) SNHG16 has been reported to be significant regulators in multiple cancers. However, never has the relationship between it and cardiac hypertrophy been studied until now. In this study, angiotensin II (Ang… read more here.

Keywords: cardiac hypertrophy; mir 182; igf1; expression ... See more keywords

Inhibition of intermittent calcium‐activated potassium channel (SK4) attenuates Ang II‐induced hypertrophy of human‐induced stem cell‐derived cardiomyocytes via targeting Ras–Raf–MEK1/2–ERK1/2 and CN–NFAT signaling pathways

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11948

Abstract: Cardiac hypertrophy caused by angiotensin II (Ang II) is essential for the pathological process of heart failure. The intermediate calcium‐activated potassium channel (SK4) has been shown to be involved in the process of the inflammatory… read more here.

Keywords: cell; hypertrophy; cardiac hypertrophy; calcium activated ... See more keywords
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Prostaglandin E2 induced cardiac hypertrophy through EP2 receptor‐dependent activation of β‐catenin in 5/6 nephrectomy rats

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recommendations! Published in 2021 at "ESC Heart Failure"

DOI: 10.1002/ehf2.13269

Abstract: Prostaglandin E2 (PGE2) is involved in the development of cardiac hypertrophy. However, whether PGE2 regulates the chronic kidney disease‐associated cardiac hypertrophy and the tentative mechanism remains to be elucidated. read more here.

Keywords: cardiac hypertrophy; induced cardiac; hypertrophy ep2; hypertrophy ... See more keywords

Tropisetron restores normal expression of BAD, SIRT1, SIRT3, and SIRT7 in the rat pressure overload-induced cardiac hypertrophy model.

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recommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"

DOI: 10.1002/jbt.23355

Abstract: Tropisetron exerts a protective effect against cardiac complications, particularly cardiac hypertrophy. Oxidative stress and apoptosis are the main contributors to the pathogenesis of cardiac hypertrophy. Sirtuins, a family of histone deacetylases, are connected to cellular… read more here.

Keywords: hypertrophy; sirt1 sirt3; expression; cardiac hypertrophy ... See more keywords

Glycosylated CD147 reduces myocardial collagen cross‐linking in cardiac hypertrophy

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.26713

Abstract: The mechanism of transition from chronic pressure overload‐induced cardiac hypertrophy to heart failure is still unclear. Angiotensin II (Ang II) may be an important factor that mediates the transition in the end‐stage of cardiac hypertrophy.… read more here.

Keywords: cardiac hypertrophy; hypertrophy; cross linking; collagen cross ... See more keywords