Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
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DOI: 10.1038/s41467-018-06193-2
Abstract: Omecamtiv mecarbil (OM) is a positive cardiac inotrope in phase-3 clinical trials for treatment of heart failure. Although initially described as a direct myosin activator, subsequent studies are at odds with this description and do… read more here.
Keywords: omecamtiv mecarbil; myosin; cardiac inotrope; working stroke ... See more keywords