Electrophysiological and ECG Effects of Perhexiline, A Mixed Cardiac Ion Channel Inhibitor, Evaluated in Non-clinical Assays and in Healthy Subjects.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1934
Abstract: Perhexiline has been used to treat hypertrophic cardiomyopathy. In addition to its effect on carnitine-palmitoyltransferase-1, it has mixed ion channel effects through inhibition of several cardiac ion currents. Effects on cardiac ion channels expressed in… read more here.
Keywords: perhexiline; ion channel; ecg effects; ion ... See more keywords
MicroRNA directly modulates cardiac ion channel
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DOI: 10.1038/s41569-021-00540-5
Abstract: A novel binding mechanism between a microRNA and an inward-rectifier potassium channel has been discovered. MiR-1 directly modulates the function of Kir2.1 to maintain cardiac homeostasis, and disruption to this relationship predisposes the heart to… read more here.
Keywords: modulates cardiac; ion channel; microrna directly; channel ... See more keywords
Antiepileptic Drug Tiagabine Does Not Directly Target Key Cardiac Ion Channels Kv11.1, Nav1.5 and Cav1.2
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26123522
Abstract: Tiagabine is an antiepileptic drug used for the treatment of partial seizures in humans. Recently, this drug has been found useful in several non-epileptic conditions, including anxiety, chronic pain and sleep disorders. Since tachycardia—an impairment… read more here.
Keywords: ion channels; drug; ion; tiagabine ... See more keywords