Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b02578
Abstract: MicroRNA-based therapy that targets cardiac macrophages holds great potential for treatment of myocardial infarction (MI). Here, we explored whether boosting the miRNA-21 transcript level in macrophage-enriched areas of the infarcted heart could switch their phenotype… read more here.
Keywords: cardiac macrophages; mirna mimic; myocardial infarction; nanoparticle delivery ... See more keywords
Cardiac macrophages team up to maintain heart health
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DOI: 10.1038/s41569-020-00461-9
Abstract: A network of macrophages in the heart supports cardiac health and function by removing dysfunctional mitochondria and waste material released from cardiomyocytes in subcellular particles called exophers. read more here.
Keywords: cardiac macrophages; heart; team maintain; maintain heart ... See more keywords
Cardiac macrophages regulate lymphatic vessel growth during heart development
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DOI: 10.1038/s41569-021-00519-2
Abstract: Tissue-resident macrophages form direct interactions with lymphatic endothelial cells and regulate the growth and sprouting of lymphatic vessels during development of the mammalian cardiac vasculature. read more here.
Keywords: cardiac macrophages; regulate lymphatic; development; growth ... See more keywords
Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy
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DOI: 10.1172/jci.insight.156236
Abstract: Takotsubo syndrome (TTS) is an acute, stress-induced cardiomyopathy that occurs predominantly in women after extreme physical and/or emotional stress. To date, our understanding of the molecular basis for TTS remains unknown and, consequently, specific therapies… read more here.
Keywords: cardiac macrophages; macrophages regulate; like cardiomyopathy; isoproterenol ... See more keywords
Chronic kidney disease mediates cardiac dysfunction associated with increased resident cardiac macrophages
Sign Up to like & getrecommendations! Published in 2022 at "BMC Nephrology"
DOI: 10.1186/s12882-021-02593-7
Abstract: Background The leading cause of death in end-stage kidney disease is related to cardiovascular disease. Macrophages are known to be involved in both chronic kidney disease (CKD) and heart failure, however their role in the… read more here.
Keywords: disease mediates; cardiac macrophages; disease; kidney disease ... See more keywords
Cardiac Macrophages and Their Effects on Arrhythmogenesis
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DOI: 10.3389/fphys.2022.900094
Abstract: Cardiac electrophysiology is a complex system established by a plethora of inward and outward ion currents in cardiomyocytes generating and conducting electrical signals in the heart. However, not only cardiomyocytes but also other cell types… read more here.
Keywords: arrhythmogenesis cardiac; macrophages effects; cardiac macrophages; effects arrhythmogenesis ... See more keywords