Epigenetically modified cardiac mesenchymal stromal cells limit myocardial fibrosis and promote functional recovery in a model of chronic ischemic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-018-0710-1
Abstract: Preclinical investigations support the concept that donor cells more oriented towards a cardiovascular phenotype favor repair. In light of this philosophy, we previously identified HDAC1 as a mediator of cardiac mesenchymal cell (CMC) cardiomyogenic lineage… read more here.
Keywords: ischemic cardiomyopathy; myocardial fibrosis; chronic ischemic; cmc ... See more keywords
Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes Promotes Repair in Ischemic Myocardium
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DOI: 10.1007/s12265-018-9822-0
Abstract: Our previous study demonstrated the beneficial effects of exosomes secreted by cardiac mesenchymal stem cells (C-MSC-Exo) in protecting acute ischemic myocardium from reperfusion injury. Here, we investigated the effect of exosomes from C-MSC on angiogenesis… read more here.
Keywords: msc exo; mesenchymal stem; ischemic myocardium; cardiac mesenchymal ... See more keywords
Abstract 16769: Intravenous Injection of Neonatal Cardiac Mesenchymal Stem Cells is a Viable Alternative Route to Treat Acute Myocardial Infarction
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DOI: 10.1161/circ.142.suppl_3.16769
Abstract: Introduction: Cardiovascular disease is major cause of morbidity and mortality around the world and major health care burden indeed. Ischemic heart disease (IHD) and myocardial ischemia (MI) are most devastating cardiovascular disease. Multiple stem cell/… read more here.
Keywords: neonatal cardiac; disease; cardiac mesenchymal; stem ... See more keywords
Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by &agr;-Ketoglutarate and TET-TDG Functional Reactivation
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DOI: 10.1161/circresaha.117.311300
Abstract: Rationale: Human cardiac mesenchymal cells (CMSCs) are a therapeutically relevant primary cell population. Diabetes mellitus compromises CMSC function as consequence of metabolic alterations and incorporation of stable epigenetic changes. Objective: To investigate the role of… read more here.
Keywords: dna; tet tdg; agr ketoglutarate; cardiac mesenchymal ... See more keywords
A Rare Case of Cardiac Mesenchymal Hamartoma and Comprehensive Review of the Literature With Emphasis on Histopathology
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DOI: 10.1177/10668969211002264
Abstract: Hamartomas are primary, benign neoplastic lesions that most commonly derive from a single variably differentiated cell lineage. Here, we report an unusual case of a cardiac hamartoma. A 62-year-old woman presented with chest pain and… read more here.
Keywords: hamartoma; mesenchymal hamartoma; muscle; histopathology ... See more keywords
Mechanisms of Regenerative Potential Activation in Cardiac Mesenchymal Cells
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DOI: 10.3390/biomedicines10061283
Abstract: Recovery of the contractile function of the heart and the regeneration of the myocardium after ischemic injury are contemporary issues in regenerative medicine and cell biology. This study aimed to analyze early transcriptional events in… read more here.
Keywords: cardiac mesenchymal; regenerative potential; mechanisms regenerative; potential activation ... See more keywords