LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway
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DOI: 10.1007/s00395-021-00887-3
Abstract: Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling of the ischemic heart. Because little is known about the involvement of long non-coding RNAs (lncRNAs) in regulating cardiac metabolism, we used unbiased transcriptome… read more here.
Keywords: heart; metabolic homeostasis; lkb1 ampk; cardiac metabolic ... See more keywords
197 Introduction of a multidisciplinary cardiac metabolic clinic in a UK tertiary cardiology centre: early activity, interventions and potential for cardiovascular risk optimisation
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DOI: 10.1136/heartjnl-2021-bcs.193
Abstract: Introduction Diabetes mellitus (DM) is associated with a doubled risk of adverse cardiovascular (CV) outcomes and a 2-5x risk of heart failure (HF) (1,2). The potential to improve clinical outcomes in patients with DM and… read more here.
Keywords: introduction; cardiac metabolic; activity; risk ... See more keywords
Fructose Metabolism and Cardiac Metabolic Stress
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DOI: 10.3389/fphar.2021.695486
Abstract: Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in… read more here.
Keywords: cardiac metabolic; metabolic stress; stress; fructose metabolism ... See more keywords
Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism
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DOI: 10.7150/thno.19551
Abstract: The growing field of cardio-oncology addresses the side effects of cancer treatment on the cardiovascular system. Here, we explored the cardiotoxicity of the antiangiogenic therapy, sunitinib, in the mouse heart from a diagnostic and therapeutic… read more here.
Keywords: receptor antagonism; sunitinib; cardiac metabolic; endothelin receptor ... See more keywords