BI1 alleviates cardiac microvascular ischemia‐reperfusion injury via modifying mitochondrial fission and inhibiting XO/ROS/F‐actin pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27308
Abstract: Pathogenesis of cardiac microvascular ischemia‐reperfusion (IR) injury is associated with excessive mitochondrial fission. However, the upstream mediator of mitochondrial fission remains obscure. Bax inhibitor 1 (BI1) is linked to multiple mitochondrial functions, and there have… read more here.
Keywords: reperfusion injury; fission; cardiac microvascular; mitochondrial fission ... See more keywords
Statins protect diabetic myocardial microvascular endothelial cells from injury
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Diabetes in Developing Countries"
DOI: 10.1007/s13410-018-0646-x
Abstract: To study the protective effect and mechanism of statins on myocardial microvascular endothelial cells injury in diabetic rats. The rats were administrated with atorvastatin (10 mg/kg/day), rosuvastatin (5 mg/kg/day), or placebo for 1 week. The expression of small… read more here.
Keywords: statins protect; myocardial microvascular; microvascular endothelial; endothelial cells ... See more keywords
Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102288
Abstract: Mitophagy preserves microvascular structure and function during myocardial ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect mitochondria. We explored whether empagliflozin could reduce cardiac microvascular I/R injury by enhancing mitophagy. In mice, I/R… read more here.
Keywords: ischemia reperfusion; empagliflozin; mitophagy; fundc1 ... See more keywords
Increased myocardial stiffness activates cardiac microvascular endothelial cell via VEGF paracrine signaling in cardiac hypertrophy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.08.014
Abstract: When the heart is subjected to an increased workload, mechanical stretch together with neurohumoral stimuli activate the "fetal gene program" and induce cardiac hypertrophy to optimize output. Due to a lack of effective methods/models to… read more here.
Keywords: cardiac hypertrophy; elastic modulus; hypertrophy; microvascular endothelial ... See more keywords
Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00606-w
Abstract: Phosphorylation of MAP4 (p-MAP4) causes cardiac remodeling, with the cardiac microvascular endothelium being considered a vital mediator of this process. In the current study, we investigated the mechanism underlying p-MAP4 influences on cardiac microvascular density.… read more here.
Keywords: related pyroptosis; microvascular density; map4; nlrp3 related ... See more keywords
L-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Acta physiologica"
DOI: 10.1111/apha.13975
Abstract: AIM To explore the beneficial effects of L-carnitine on cardiac microvascular dysfunction in diabetic cardiomyopathy from the perspectives of mitophagy and mitochondrial integrity. METHODS Male db/db and db/m mice were randomly assigned to groups and… read more here.
Keywords: cardiac microvascular; parl; cpt1a; mitophagy ... See more keywords
QiShenYiQi Pills Attenuates Ischemia/Reperfusion-Induced Cardiac Microvascular Hyperpermeability Implicating Src/Caveolin-1 and RhoA/ROCK/MLC Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.753761
Abstract: Aims: Coronary microvascular hyperpermeability is an important contributor to ischemia or reperfusion (I/R) injury. However, the effective strategy for this insult remains limited. This study aimed to explore the protective effect of the compound Chinese… read more here.
Keywords: hyperpermeability; src caveolin; rhoa rock; microvascular hyperpermeability ... See more keywords
Substance-P Inhibits Cardiac Microvascular Endothelial Dysfunction Caused by High Glucose-Induced Oxidative Stress
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DOI: 10.3390/antiox10071084
Abstract: Diabetes is characterized by high glucose (HG) levels in the blood circulation, leading to exposure of the vascular endothelium to HG conditions. Hyperglycemia causes oxidative stress via excessive reactive oxygen species (ROS) production in the… read more here.
Keywords: dysfunction; high glucose; cmecs; cardiac microvascular ... See more keywords